Scientist I/II, Stem Cell Biology - CNS

Location
South San Francisco, CA, United States
Posted
Apr 30, 2021
Ref
4983790002
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we'll develop for a range of severe diseases.

We are seeking a talented and highly motivated researcher with strong background in neurobiology to develop pluripotent stem cell models for diseases of the CNS. The successful candidate will have deep expertise in developing complex assays using neuronal and glial cultures. Additional experience with CRISPR gene editing, CRISPR screens, and high-throughput biology is preferred. As a core member of the stem cell group, you will work independently on experiments using cutting edge functional genomics and biological methods. This is an exciting interdisciplinary role in a dynamic cross-functional team that will contribute directly to the identification of new targets and the design and validation of novel disease-modifying therapeutics.

Your Role in Navigating the Maze:
  • Establish and scale hiPSC differentiation protocols into various lineages including neurons, astrocytes and microglia
  • Contribute strategically and creatively to in vitro assay design and optimization
  • Develop complex assays for target discovery, target validation, biomarker discovery, and molecular modeling of disease to support drug discovery programs
  • Work alongside the functional genomics team to develop and optimize CRISPR screens in neuronal cells
  • Collaborate closely with other scientists, bioinformations, and computational biologists
  • Present findings and data analysis in research meetings

Your Navigation Tools:
  • Ph.D. in a biological discipline with relevant research experience, or M.S. with 5+ years of relevant experience
  • Strong background in neurobiology
  • Extensive experience in culturing and developing assays in neuronal cells
  • Demonstrated experience in utilizing hESCs/hiPSCs for disease modeling of neurological disorders, preferably in a drug discovery or industry setting
  • Demonstrated experience and expertise in differentiation of hESCs/hiPSCs into neurons and glia
  • Extensive experience with cell-based assay development using wide range of assays including but not limited to ELISA, q-PCR, single-cell RNA seq, flow cytometry, confocal microscopy, and high-content imaging
  • Experience with CRISPR gene editing and pooled/arrayed CRISPR screens is preferred
  • Experience with laboratory automation is a plus
  • Demonstrated record of success with a strong publication record
  • Organized, detail-oriented, excellent record-keeping skills, excellent verbal and written communication skills
  • Ability to work independently and perform well in a team environment