Research Scientist Antibody Engineering & Protein Sciences

Emeryville, CA
Competitive Salary, Bonus, Benefits including Medical, Dental, Vision, Share Options, 401 (K)Match
Apr 28, 2021
Required Education
Position Type
Full time

The Research Scientist position will report to the leader of the Protein Chemistry group and will support therapeutic antibody discovery campaigns.  This position will focus on antibody characterization and optimization. A successful candidate will have strong technical skills and hands-on experience in biochemistry, molecular biology, structural biology or a related field. Must be able to independently design and execute experiments. Must have a good theoretical understanding of protein chemistry. Strong communication and collaboration skills are required.

The OmniAb group at Ligand consists of dynamic and innovative scientists that employ a variety of novel platforms to support our partners in discovering the best antibodies possible for their therapeutic applications.  At the core of OmniAb is the ability to engineer animals to generate affinity matured human sequence antibodies for use in conventional and novel formats.  We leverage our proprietary animals with state-of-the-art technology in antigen design, immunization methods and high-throughput single B cell screening to facilitate discovery of best-in-class antibodies.   We are looking for accomplished team players who are enthusiastic to contribute to the technological frontier of antibody discovery, and passionate in their desire to collaborate with partners to develop next generation therapeutics.  See for more details about the exciting science being performed at Ligand

Essentials for Working at Ligand    •    Ligand is a dynamic, fast-paced organization committed to creating shareholder value and addressing unmet medical needs through developing and acquiring cutting-edge, royalty-bearing technologies and establishing research collaborations that make major life-saving global drugs possible.  To be successful at Ligand, employees must be innovative, efficient, versatile, self-starters who take great pride in their work and want to contribute to something significant.

Essential Role Responsibilities

  • Independently plan and carry out antibody expression, purification and analysis
  • Conduct PCR, molecular cloning and site-directed mutagenesis
  • Design and execute analytical assays of antibody properties
  • Perform transfections and propagate mammalian tissue culture cell lines
  • Maintain an accurate electronic lab notebook and present data at group meetings
  • Prepare experimental data reports for partner and internal antibody discovery programs

Non-essential Role Responsibilities Include

  • Deliver presentations at major antibody conferences
  • Other duties as required

Minimum Requirements

  • PhD with 2+ years relevant experience
  • BS or MS in Biology or equivalent, with extensive industry experience (7-12 years) including antibody discovery
  • Experience in antibody cloning, expression and/or purification
  • Experience in antibody engineering
  • Experience with techniques for antibody characterization such as BLI/SPR, ELISA, FACS and cellular assays
  • Experience in mammalian cell culture
  • Experience in yeast or phage display is preferred
  • Experience in project management is preferred
  • Eagerness to learn new methods and apply knowledge to a steady stream of new projects with distinct goals
  • Must demonstrate well-developed communication, record keeping, organizational skills, and the ability to work in a team environment



  • The company offers competitive benefits including medical, dental, vision, Short/Long term disability and life insurance, as well as 401(k) match, Stock Options, Bonus, and paid time leave

Additional Information

  • All new hires are required to go through a background and reference check
  • Ligand is an EEO/AA/Disability/Vets employer
  • Must be legally authorized to work in the US without sponsorship
  • Ligand celebrates the diversity of life and welcomes all individuals to apply