Scientist, Bioconjugation Chemistry

Location
Cambridge, MA
Posted
Apr 26, 2021
Hotbed
Genetown
Required Education
Bachelors Degree
Position Type
Full time

Company Overview

Orum Therapeutics is a private biotech company located in Daejeon, Korea, and Cambridge, Massachusetts. We are developing a novel class of therapeutics to bring new medicines to patients with unmet medical needs. Orum leverages its proprietary antibody, conjugation, and medicinal chemistry platforms to inhibit or degrade intracellular target proteins. We are advancing our first set of oncology candidates toward preclinical development.  

 

The Role

Orum Therapeutics is seeking to expand our in-house protein chemistry and bioconjugation capabilities to help advance quality compounds toward the clinic. The successful candidate will have a strong background in chemistry or biochemistry and a passion for driving high-impact projects in the anti-cancer drug discovery space. He/she will conduct bench-based research focused on synthesizing and characterizing new chemical entities for testing as potential therapeutics.

 

Responsibilities

  • Synthesize bioconjugates using established (e,g, lysine, endogenous cysteine, site-specific) chemistries and contribute to the development of new methodologies

  • Purify bioconjugates by different modes (e.g. SEC, affinity, UF/DF) using benchtop and automated (e.g. AKTA FPLC) methods

  • Characterize bioconjugates using multiple techniques (e.g. UV/Vis, HPLC, and MS)

  • Present written and oral reports to multidisciplinary teams

  • Contribute to the build-out and upkeep of an expanding laboratory through maintaining shared equipment, assisting with general laboratory housekeeping, and developing processes for improving workflow efficiency

 

Requirements and Qualifications

  • BS/MS in organic chemistry, biochemistry, or a related field with at least 1-2 years research experience in a laboratory setting

  • Hands-on experience with chemical modification, purification, and characterization of proteins required

  • Previous hands-on experience with antibodies and antibody-drug conjugates is a plus

  • Enthusiasm for collaborating with multidisciplinary teams of chemists, protein engineers, and biologists

  • Proficiency with operating common laboratory equipment and maintaining laboratory infrastructure

 

Please send your resume and cover letter to apply (Title field: Full Name_Bioconjugation Chemistry)