Research Associate - DMPK

Location
Hayward, California
Posted
Apr 26, 2021
Ref
208
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time

Arcus Biosciences is seeking a highly motivated and team-oriented individual for the position of Research Associate in the Drug Metabolism and Pharmacokinetics (DMPK) Department. The successful candidate will be responsible for conducting routine in-vitro ADME studies, qualitative and quantitative analysis of small molecules using LC-MS/MS, to support multiple drug discovery and development projects.

 

Responsibilities include, but are not limited to:


  • Perform LC-MS/MS method development and quantitative analysis of small molecules in various biological matrices.
  • Conduct routine in vitro metabolic stability assays such as hepatocyte stability and microsomal stability assays.
  • Perform other in vitro ADME studies such as plasma protein binding and blood to plasma partitioning as needed.
  • Identify soft-spots and major metabolism pathways of small molecules in the in vitro system using LC-MS/MS.
  • Perform data analysis and reporting of experimental results to project teams.
  • Maintain and troubleshoot LCMS instruments.

 

Qualifications:


  • BS/MS degree in chemistry, pharmaceutical science, or related scientific discipline with 1-4 years of relevant experience
  • Solid background in organic chemistry and analytical chemistry
  • Hands-on experience in LC/MS/MS method development and quantitative analysis of small molecule using LC/MS/MS instruments, preferably SCIEX 4000, 5500 or 6500 series
  • Experience with in vitro ADME assays is highly desirable.
  • Experience with Thermo Orbitrap and liquid handling systems is a plus.
  • Detail-oriented, strong work ethic, self-motivated, and proven ability to work both independently and collaboratively in a team environment
  • Excellent communication and writing skills