Chemical Informatics and Laboratory Automation Specialist

Location
San Francisco, CA, United States
Posted
Apr 25, 2021
Ref
5160908002
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
Nurix is looking for a Chemical Informatics and Laboratory Automation Specialist to join our growing automated chemistry team. The successful candidate will design and implement tools and applications for chemists to manage the planning and execution of automated, high throughput compound synthesis. You will partner with chemists, data science, software development, informatics, and IT to create database backed workflows and processes to streamline:
  • Enumeration of virtual libraries
  • Stepwise management of library compound synthesis including:
    • Instrument worklist generation
    • Instrument output processing
  • Compound registration
  • Sample Management
  • Management of chemical building blocks
  • Management of reaction schemes

Your solutions will enable chemists and management to track libraries as they progress from idea through synthesis, purification, analysis and into inventory, as well as provide metrics that enable assessment of library quality, efficiency, and capacity.

Required Qualifications
  • BS or higher in Chemistry
  • Strong background in computerized chemical representation and transformation with an emphasis on stereochemistry – SDF (V2000/V3000), SMILES/SMARTS/SMIRKS, RDF
  • Expertise authoring requirements/specifications, workflow/process diagrams, and project plans
  • Minimum 5 years experience with industry standard applications such as ChemCart, Dotmatics, GeneData, Benchling, Sample Manager, LabWare, and/or LabVantage
  • Demonstrated programming expertise in the following:
    • SQL (Oracle, PostgreSQL)
    • Visual Basic/VBA
    • Python/Perl/Java
  • Excellent verbal and written communication skills
  • Experience in managing contractors and vendors
  • Expertise in MS Office (Excel, Word, PowerPoint, Visio)

Preferred Skills
  • Experience working with data-analysis/pipelining/visualization tools and applications such as Pipeline Pilot, Knime, R/Shiny, Spotfire, and/or Tableau
  • Minimum 2 years experience programming Lab instruments
    • Hamilton Vantage liquid handler
    • Waters/Agilent LCMS and preparative HPLC
  • Strong QA background

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix's drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.