Manager, Core Lab - NGS

Menlo Park, CA, United States
Apr 23, 2021
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by developing pioneering technology to detect and identify multiple deadly cancer types early. The company is using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology, and to develop its multi-cancer early detection blood test. GRAIL is headquartered in Menlo Park, CA with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies. For more information, please visit

GRAIL is seeking a Manager to lead the LabOps Core Lab team, who will be primarily responsible for ensuring the efficient execution of GRAIL assays in support of R&D activities and pharma partnerships. The candidate will be leading the development and growth of a new team that will need to be staffed and trained on a variety of GRAIL assays. The ideal candidate is a detail-oriented, dynamic team player with deep experience in both automated and manual NGS assay execution. The candidate will be expected to partner with many functions of our organization - Automation, Product Development, LIMS, Quality, Supply Chain, Biosample Operations, and the Clinical Lab - to forecast for upcoming activities, delegate work to direct reports, and be instrumental in the implementation and operation of the Core Lab.

Duties & Responsibilities:

• Coordinate the forecasting and execution of experiments with various stakeholders including R&D, Biosample Operations, and Supply Chain
• Become an expert on current production assays and legacy manual workflows
• Be responsible for accurately recording work performed per GLP
• Lead a team of research associates in the planning and execution of various NGS workflows
• Actively participate and engage in the development and testing of new assays and technologies in collaboration with R&D
• Ensure laboratory activities are performed in compliance with procedures and safety guidelines when handling, storing and disposing of hazardous or bio-hazardous materials

Minimum Qualifications:

• B.S required, advanced degree strongly preferred in a relevant field
• 4+ years of experience in Next Generation Sequencing assays and workflows
• Direct management experience having hired, trained, and led high performing teams in a fast paced production-like environment
• Experience with Automated sample preparation workflows
• Proficient with basic molecular biology laboratory techniques including but not limited to (e.g. pipetting, SPRI, PCR, qPCR)
• Familiarity with nucleic acids extraction techniques and quantification devices (e.g., Nanodrop, Bioanalyzer, Fragment Analyzer, ddPCR)
• Excellent teamwork and collaboration skills with outstanding written and verbal communication skills
• Self-directed, innovative, and creative thinker
• General computer skills and proficiency in GSuite

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

GRAIL, Inc. and its affiliates and subsidiaries ("GRAIL") does not accept any liability for fees for resumes from recruiters or employment agencies ("Agency"), without a binding, written recruitment agreement between GRAIL and Agency describing the services and specific job openings ("Agreement"). GRAIL may consider any candidate for whom an Agency has submitted an unsolicited resume and explicitly reserves the right to hire those candidate(s) without any financial obligation to the Agency, unless an Agreement is in place. Any email or verbal contacts with any person within GRAIL is inadequate to create a binding agreement. Agencies without an Agreement are requested not to contact any hiring managers of GRAIL with recruiting inquiries or resumes. Agencies interested in partnering with GRAIL may contact GRAIL's HR Department through our Customer Service team .