Scientist, Discovery Biology and Protein Biochemistry

South San Francisco, California
Apr 20, 2021
Biotech Bay
Required Education
Position Type
Full time
BridgeBio finds, develops, and delivers breakthrough medicines for genetic diseases. The company bridges remarkable advancements in genetic science with the entrepreneurial engine required to rapidly create lifesaving medicines for patients with unmet needs. Founded in 2015 by a team of industry veterans, the company has built a portfolio of 20 transformative drugs ranging from pre-clinical to late-stage development in multiple therapeutic areas including genetic dermatology, oncology, cardiology, neurology, endocrinology, renal disease, and ophthalmology. The company’s focus on scientific excellence and rapid execution aims to translate today’s discoveries into tomorrow’s medicines. We have offices in San Francisco, Palo Alto, Boston, New York, and Raleigh, with small satellites in other parts of the country. 

To learn more, visit us at

Who You Are:

Do you want to be a part of the next-level discovery team to test “moonshots” in genetic disease at BridgeBio? We seek an entrepreneurial Scientist to work on high-risk, high-reward programs within a culture that celebrates failures, as long as they were scientifically rigorous and conclusive. The projects within this team need someone with a wide variety of experience in various biological systems, deep knowledge in protein biochemistry and molecular biology, and expertise in cutting-edge techniques within mass spectrometry, protein purification, structural biology, etc. Because you will be working on various programs, we hope you will have broad interests and experience with versatile techniques.

You will lead discovery and development assays for some of the most challenging and high-impact genetic diseases and bring our early discovery, pre-clinical programs to the next level. If you have expertise in developing and optimizing various biophysical, biochemical, molecular, and cellular assays and want to be on the ground floor as we build this internal capability at BridgeBio, we want to hear from you.

  • Drive basic research towards the clinic at hyper-speed 
  • Independently design, execute and analyze experiments within our top-notch laboratory
  • Communicate findings and implications to senior leadership
  • Help drive overall pre-clinical strategy 
  • Collaborate with the business development team to assess and understand a variety of rare diseases
  • Use a variety of biochemical, cellular, biophysical, and pharmacological techniques to advance multiple candidates from discovery research to clinical development

Education, Experience & Skills Requirements:
  • Ph.D., MD, or Ph.D./MD degree and expertise in a relevant scientific field (e.g., biochemistry, molecular biology, chemical biology, chemistry, structural biology)
  • 2+ years of postdoctoral experience
  • Experience and familiarity with techniques used for protein purification
  • Experience with a wide range of biophysical (mass spectrometry (MS), surface plasmon resonance (SPR), microscale thermophoresis (MST) dynamic light scattering (DLS)) and plate-based biochemical (FRET, MSD, ELISA) techniques
  • Strong knowledge of chemistry concepts, including an understanding of structure-activity relationships (SAR) and structure-based inhibitor design
  • Experience with other molecular and cellular biology techniques, such as functional assay development, immunohistochemistry (IHC), Western blot, qPCR, etc.
  • Demonstrated record of achievement as evidenced by first-author publications, grants, scholarships, or awards

What We Offer:
  • Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts
  • A culture inspired by our values: put patients first; think independently, be radically transparent; every minute counts, and let the science speak
  • Learning and development training to help employees be the best version of themselves
  • Collaborative business environment
  • Excellent compensation package (Base, Performance Bonus, Stock, RSU programs)
  • Excellent benefits package
  • Flexible PTO
  • With office locations in San Francisco, Boston, New York, and Raleigh, there are ample cross-collaboration opportunities with other BridgeBio Pharma programs
  • A fast-paced, data-driven, work environment with world-class R&D minds and capabilities
  • Work with the most productive groups of R&D operators in the industry
  • Partnerships with leading institutions
  • A platform for meaningful scientific contributions to shine
  • Commitment to Diversity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels respected for who they are, empowered to contribute, inspired to lead, and supported in their efforts to do so

We will not accept unsolicited resumes from agencies. Please do not send agency resumes to our website or BridgeBio and affiliating employees.