Senior Research Associate, Process Development

Thank you for your interest in a career at Senti Biosciences. Our mission is to create a new generation of smarter medicines that outmaneuver complex diseases in ways previously inconceivable. We are passionate about designing gene circuits to improve the "intelligence" of cell and gene therapies in order to enhance their therapeutic effectiveness against a broad range of diseases that conventional medicines are unable to address.

At Senti, we find purpose and meaning knowing that our efforts have the potential to improve the lives of patients and their families with more effective and safer treatment options. With science as our foundation and empathy as our key guiding principle, colleagues become friends, managers become mentors, and with time, cancer becomes history.

Senti Bio is seeking a Senior Research Associate or Associate Scientist to join our Process Development team for our cell therapy programs. The successful applicate will have prior experience with process development and scale up of gene modified cell therapies and be comfortable in a fast moving and nimble culture. Applicants should be familiar with culture expanded cell products (e.g. CAR-NK cells and CAR-T respectively), comfortable with pre-clinical process development and GMP tech transfer to a CDMO, and familiar with analytical methods development and implementation. We are seeking individuals who are passionate about the future of "smart therapeutics" and have the energy and boldness to thrive and grow in a dynamic and fast startup environment.

Responsibilities

• Contribute to process development for cell therapy development programs, including natural killer cells (NK cells), CAR-T cells and other therapeutic cell modalities.
• Perform transductions on primary human cells via viral vectors and other gene delivery methods
• Develop and perform assays that measure function of virus and modified cells
• Independently perform experiments on process conditions and raw material qualification
• Develop internal bioreactor-based generation of genetically modified cells under quality-controlled conditions suitable for transfer to a GMP facility.
• Play a central role in interaction with contract manufacturers, key suppliers, and other external vendors.
• Successfully execute and document laboratory procedures and experiments with great attention to detail
• Maintain accurate lab records and notebooks
• Author protocols, reports and standard operating procedure documents

Qualifications

• Bachelor's Degree in a Life Science related field
• 5 years of relevant experience
• Experience with mammalian tissue culture including both adherent and suspension cells
• Experience with gene delivery methods (e.g. transduction) and related functional assays
• Bioreactor experience (WAVE) is a plus
• Previous experience working in an industry setting is a plus
• Experience with clinical scale magnetic cell enrichments and depletions in and closed-system cell therapy manufacturing processes is a plus
• Proficiency with flow cytometry strongly preferred
• Ability to design and execute experiments with minimal technical supervision. Ability to multitask and meet deadlines in a fast-paced environment
• Ability to think critically and demonstrate troubleshooting and problem-solving skills
• Experience with performing technology transfers to GMP Contract Manufacturing Organizations
• Familiarity with Quality Documentation and Systems
• Must be a team player, proactive and willing to work in a small team environment
• Must have excellent verbal and written communication skills
• Proficient with MS office and other commonly used software and technology platforms
• Self-motivated and eager to take on temporary responsibilities outside of initial job description.

Salary and Benefits

• Competitive compensation package and title commensurate with qualifications and experience in the South San Francisco Biotech market including:

- Generous 401k instant-vesting employer match

- Healthy snacks and daily lunch program

- Medical, Dental, Vision, Life & Disability benefits

- EAP, Concierge Service, Recognition Awards and Career Development Opportunities

• Significant career growth opportunity as the company develops

Senti Bio is a leading gene circuit company designing gene circuits to create a new generation of "smarter medicines" and enhance the therapeutic effectiveness of cell and gene therapies against a broad range of diseases that are unaddressed by current standards of care. We are proud to count Leaps by Bayer, NEA, 8VC, Matrix Partners China, Mirae Asset Capital, Amgen Ventures, Intel Capital, Ridgeback Capital, Lux Capital, KB Investment, Pear VC, Smilegate Investment, Menlo Ventures, LifeSci Venture Partners, Alexandria Venture Investments, Allen & Company, LifeForce Capital, Omega Funds, Nest.Bio, Gaingels, Noveus Capital, and Goodman Capital among our investors. Senti Bio is based in South San Francisco, CA, USA.