Senior Associate Scientist (Cell Assay Development))
At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through science.In oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
We are seeking a motivated and innovative scientist to join Cell Assay Development (CAD) team within Discovery Biotherapeutics. CAD team serves as an interface between multidisciplinary teams across Protein Science and Biology. This position has a core emphasis on establishing, optimizing and executing essential bio-assays that facilitate functional characterization on antibodies or protein-based therapeutic leads in low to high throughput. The successful candidate is expected to be a good team player that closely interact with research teams from Biology, Antibody Discovery, Automation Technology, Protein Engineering and Recombinant Proteins. In addition to assay development, this candidate will also involve in cell engineering works to generate over-expressed, knock-out or knock-in cell materials.
- Profile receptor density, signaling pathways and promoter activity on key assay cell lines
- Validate and optimize existing assay protocols to drive performance
- Maintain, characterize and curate key cell line materials
- Support data generation and analysis according to specific projects
- Survey literatures, patents, commercial kits and transform the information into new workflow for assay use
- (Occasional) Engineer cell lines to create new functional read-out
- B.S.(+3 years working experience) or M.S.(+2 years working experience) in Biomedical science, Cell biology, Immunology, Cancer biology, Molecular biology, Biochemistry or related fields
- Strong cell culture experience is necessary
- Experience using antibodies or small molecules in biological assays
- Working experience on cell-based assays (e.g. viability analysis, signal transduction, ligand/receptor binding, protein turnover rate, cytokines quantification, promoter activity measurement)
- Hands-on experience with reporter assays, ELISA, HTRF or AlphaLISA is desirable
- Basic flow cytometry experience
- Molecular cloning skills (PCR-based or fragment assembly)
- Proficient with basic data analysis and visualization software (Excel, Prism, Flowjo etc.)
- Excellent written, oral, and organizational skills
- (Plus) Isolation of primary immune cells from blood samples
- (Plus) Cell line engineering experience via transient transfection, lentivirus or CRISPR/Cas9
- (Plus) Protein purification experience
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to firstname.lastname@example.org. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.