Research Associate / Senior Research Associate, Functional Genomics (Contract)
- Employer
- Maze Therapeutics
- Location
- South San Francisco, CA, United States
- Start date
- Apr 14, 2021
View more
- Discipline
- Science/R&D, Research, Genomics
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- Biotech Bay
Job Details
We are seeking a talented and highly motivated Research Associate with cell line engineering experience to join our functional genomics team. These individuals will collaborate closely with colleagues from our therapeutic area teams to develop design and build engineered cell lines and develop assays using a variety of readout technologies, execute screens, and follow-up hits. These individuals will also help establish our laboratories and the infrastructure for screening operations in collaborations with colleagues in our research infrastructure and data science teams. This person will support functional genomics scientists in genome screens such as CRISPR, and will do cellular work in support of new screenings.
Education and Experience:
Candidates for these positions should have a BS/MS in a biological science discipline and at least 2 years of relevant experience in a pharmaceutical, biotechnology, or 5 years in an academic setting. Ideal candidates will have a depth of experience in molecular biology and cell-line engineering experience
Required Skills:
- Broad laboratory experience and skills in molecular and cell biology is required.
- Expertise with mammalian cell culture is required, and Next Gen Sequencing methodologies is preferred.
- Experience with cell line engineering using random integration and lentivirus transduction is required. Expertise in cell line engineering via CRISPR is preferred.
- Expertise in single cell cloning via limiting dilution and in using flow sorting to generate stable cell pools is required.
- Experience in gDNA and RNA isolation, RT-PCR, and NGS library generation is preferred.
- Excellent data analysis skills and experience with a variety of scientific software applications is required. Successful candidates will also have strong experimental design and troubleshooting skills.
- Excellent communication, presentation, collaboration, time-management, and organizational skills and are required.
- The successful candidates will be ambitious and energetic self-starters, be motivated to apply their skills and creativity to target and drug discovery, and enjoy working in a fast-paced team environment.
Company
Maze Therapeutics is translating novel genetic insights into lifesaving medicines, through an approach that integrates human genetics and functional genomics. Advances in these areas have enabled us to decode the mysteries of genetic modifiers in a range of severe diseases, which we aim to turn into medicines that mimic protective mutations.
What are genetic modifiers?
Despite an understanding of the genetic basis for many diseases, it remains a mystery why some people with a disease-causing mutation never get sick. This is often due to genes elsewhere in our DNA that affect the severity of disease and can provide a natural form of protection.
The Maze approach
Dramatic advances in human genetics and functional genomics now enable us to decode the mysteries of genetic modifiers in a range of severe diseases. Today, we believe we can systematically identify genetic modifiers and turn these insights into medicines. We have assembled a world-class team to realize this vision, including creative scientific pioneers, experienced company builders and biotech industry leaders.
Join us in our pursuit to change lives by translating genetic insights into medicine - view our job postings with the link to the left.
- Website
- https://mazetx.com/
- Location
-
171 Oyster Point Blvd, Suite 200
South San Francisco
CA
94080
United States
Get job alerts
Create a job alert and receive personalized job recommendations straight to your inbox.
Create alert