Senior Scientist, Translational Research (Oncology)

Location
Austin, TX, USA
Posted
Apr 14, 2021
Ref
217131
Hotbed
Lone Star Bio
Required Education
Other
Position Type
Full time
Company Overview:

Molecular Templates is a clinical stage biopharmaceutical company focused on the discovery and development of differentiated, targeted, biologic therapeutics for cancer. We believe our proprietary biologic drug platform technology, referred to as engineered toxin bodies, or ETBs, provides a differentiated mechanism of action that may address some of the limitations associated with currently available cancer therapeutics. ETBs utilize a genetically engineered form of Shiga-like Toxin A subunit, or SLTA, a ribosome inactivating bacterial protein, that can be targeted to specifically destroy cancer cells. Additional information about Molecular Templates can be obtained at www.mtem.com

Position Overview:

We are seeking a highly motivated scientist with a strong background in clinical immunology assays to identify, design, develop and execute on lab-based translational research projects in oncology and immune-oncology programs supporting preclinical and clinical efforts for the Translational and Early Development team. This individual will take on leadership efforts in working with both internal R&D colleagues and external partners to support and execute of these efforts. Our ideal candidate must be able to handle a dynamic and fluid environment in support of efforts to bring new therapies to patients.

Job Responsibilities will include:
  • Manage clinical PD, and biomarker sample logistics as laid out in study protocol, and coordinate between the central laboratory and testing facilities as well as manage external laboratories supporting these efforts
  • Design, plan out various PK/PD endpoints in early development clinical studies to enable RP2D identification for oncology programs.
  • Manage timelines for sample testing and data transfer with external vendors and/or internal teams.
  • Single point of contact for all clinical sample management. Manage sample transfer/discrepancy resolution with Central Lab, Clinical Site. CRO vendors.
  • Manage on-site storage of preclinical samples with routine inventory reviews
  • Work with Translational Science team to identify vendors, plan and execute on novel PD assays to determine drug activity.
  • Research and development of Biomarker execution strategy for new projects.
  • Coordinate agreements between MTEM and external vendors in support of these efforts
  • Assist in the development and maintenance of a central biorepository database (e.g. Laboratory Information Management System)
  • Review and provide feedback on clinical study protocols, laboratory documents, and service provider laboratory scope of work documents for sample handling details
  • Consistent evaluation of improvement to processes

Qualifications:
  • PhD in Biochemistry/Molecular Biology, Immunology, Pharmacology, or a related field, and postdoctoral experience is highly preferred with 8 years+ experience in pharmaceutical or biotechnology industry, ideally in preclinical development and/or in basic research of therapeutics.
  • Hands-on technical proficiency and understanding the basis/background of key PD assays, i.e. flow cytometry/CyTOF, GEP, RNAseq, high resolution sequencing, multiplexed immune assays, cytokine assays, ELISAs, RT-qPCR, IHC as well as other skills are highly desired.
  • Effective organization, planning, and time management
  • Minimum 5 years industry (or academic) experience in the development and execution of Clinical Biomarker Assays, preferentially in oncology studies with assays described above is preferred.
  • Flexibility and resilience are required to work in dynamic environment. Proven ability to work under pressure and deadlines.
  • Excellent communication and written skills.
  • Proven productivity as demonstrated by publications/presentations/patents in key meetings or peer reviewed publications
  • Ability to master the use of key software is a bonus (Spotfire, JMP or others)
  • Technical knowledge to maintain electronic files and experience with database entry (e.g. LIMS/ELN) is a bonus


Reporting Structure: This position reports to the SVP, Translational Medicine and Non-Clinical Development.

Molecular Templates celebrates and supports our differences and is proud to be an Equal Employment Opportunity employer. We do not discriminate based upon race, religion, color, national origin, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, veteran status, disability, or any other legally protected characteristic. 

MTEM is committed to providing reasonable accommodations for qualified individuals. If you need assistance with your application due to a disability, you may contact us at: careers@mtem.com.

By submitting a resume for consideration, applicants verify that they have read MTEM's Applicant Privacy notice. https://www.mtem.com/privacy-policy

Molecular Templates Inc https://mtem.isolvedhire.com