Skip to main content

This job has expired

You will need to login before you can apply for a job.

Scientist I/II, Protein Sciences (Cryo-EM Structural Biologist)

Employer
Maze Therapeutics
Location
South San Francisco, CA, United States
Start date
Apr 10, 2021

View more

Discipline
Science/R&D, Biology, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Biotech Bay
Send job

Job Details

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we'll develop for a range of severe diseases.

We are seeking a talented and highly motivated scientist with a strong background in cryo-EM structural biology (Cryogenic electron microscopy) to join our dynamic and highly-collaborative protein sciences team. The successful candidate will work independently to solve structures of small molecule-bound protein complexes, including preparing cryo-EM grids and assisting with data collection. The candidate will also have opportunities to help establish cryo-EM workflows and implement and automate processing software. As a member of the drug discovery team, you will work independently and collaborate with team members across disciplines and present results in team meetings.

Your role in Navigating the Maze
  • Process single particle cryo-EM data, including handling raw data, interpretation, 3D reconstruction and map refinement, and model-building for diverse projects
  • Prepare cryo-EM and negative stain samples
  • Express and purify recombinant proteins and protein-protein complexes
  • Support drug discovery efforts by obtaining atomic resolution single particle cryo-EM structures of protein targets bound to inhibitors
  • Support high-performance structural biology computing infrastructure including management of large data storage and processing clusters
  • Train scientists in cryo-EM data processing using state-of-the-art software for 3D reconstructions, atomic model building, and in fundamentals of cryo-EM sample handling and preparation
  • Evaluate and implement new technology to advance protein sciences at Maze

Your Navigation tools
  • PhD or equivalent in structural biology, biophysics, biochemistry or a related field with documented experience in cryo-EM of proteins
  • Experience with cryo-EM sample preparation protocols including negative staining and sample vitrification
  • Strong expertise in single particle cryo-EM image processing and 3D reconstruction (expertise using programs such as RELION, CryoSPARC)
  • Expert on data-processing and structure solution of protein-protein complexes and membrane protein complexes
  • Hands-on experience in modern protein purification and chromatography techniques. Knowledge of biochemical and biophysical assays (MST, DSF, SPR) to characterize binding interactions would be an advantage
  • Experience with Linux OS (installation, configuration, and maintenance)
  • Experience with software for model-building and refinement such as CCP4-em, Coot etc.
  • Demonstrated record of success with a strong publication record
  • Organized, detail-oriented, excellent record-keeping skills, excellent verbal and written communication skills
  • Ability to work independently and perform well in a team environment

Company

Maze Therapeutics is translating novel genetic insights into lifesaving medicines, through an approach that integrates human genetics and functional genomics. Advances in these areas have enabled us to decode the mysteries of genetic modifiers in a range of severe diseases, which we aim to turn into medicines that mimic protective mutations. 
 
What are genetic modifiers?
 
Despite an understanding of the genetic basis for many diseases, it remains a mystery why some people with a disease-causing mutation never get sick. This is often due to genes elsewhere in our DNA that affect the severity of disease and can provide a natural form of protection.
 
The Maze approach
 
Dramatic advances in human genetics and functional genomics now enable us to decode the mysteries of genetic modifiers in a range of severe diseases. Today, we believe we can systematically identify genetic modifiers and turn these insights into medicines. We have assembled a world-class team to realize this vision, including creative scientific pioneers, experienced company builders and biotech industry leaders.
 
Join us in our pursuit to change lives by translating genetic insights into medicine - view our job postings with the link to the left.

Company info
Website
Location
171 Oyster Point Blvd, Suite 200
 South San Francisco
CA
94080
United States
Send job

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert