Senior Scientist I, Organic Chemistry – Oncology Synthesis Group
AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.
The Oncology Synthesis Group (OSG) is a team of synthetic organic chemists that work at the interface between Medicinal and Process Chemistry. The group works directly with Oncology Discovery project teams from pre-Lead Optimization through the clinical candidate nomination process. The team is charged with providing chemistry strategies, novel cores and intermediates for SAR, optimized routes for final API and is expected to be a source for synthetic expertise. As the project team proceeds towards a clinical candidate, our group of chemists provide scale-up support for toxicology studies and transfer high-quality synthetic routes to the Process Chemistry team. Chemists in the Oncology Synthesis Group are exposed to several projects at once and are expected to collaborate with all relevant support groups to achieve project and Oncology goals. The applicant must have a passion for hands on synthetic organic chemistry.
Primary Job Function: Conceive and execute synthetic organic chemistry research and development that achieves project and area goals. Provide high-quality intermediates and final API for the Medicinal Chemistry teams and toxicology studies. Generate new scientific proposals and lead those efforts to advance our understanding of project chemistry. Investigate, identify, develop, and optimize new methods/ techniques. Act as a lead scientist in his/her area of expertise on one or more projects. Critically evaluate relevant scientific advances and integrate this knowledge into research programs.
Core Job Responsibilities: Maintain a high level of productivity in the laboratory. Demonstrate the ability to resolve key project hurdles and assumptions by effectively utilizing available information and technical expertise. Proactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program. Publish research in peer-reviewed journals and present work at scientific conferences. Effective writer and communicator of research or other regulatory materials. Present research at group and project meetings.
Position Accountability/Scope: Demonstrate a high degree of responsibility in maintaining scientific standards, and safe laboratory practices for self and reporting staff, if any. Participate in establishing project goals, defining short and long-term chemistry strategies, and contribute to the generation of project-related documents and presentations. May supervise one or more direct reports and proactively engage in their development. Keep accurate and current records of research and/or project related activities according to AbbVie policies.
Internal/External Contacts and Interactions: Use external information to gain competitive intelligence. Act as advocate to integrate this knowledge into the group's research efforts. Generate new research or development strategies to effectively address project and divisional goals/needs. Collaborate with functional and technical experts to facilitate scientific achievement. Publish project-related research in high-impact factor peer-reviewed journals, R&D reports, patent applications and/or regulatory documents/filings. Responsible for compliance with applicable Corporate and Divisional Policies and procedures.
- BS, MS, or PhD in Organic Chemistry or related field. Postdoctoral or pharmaceutical industry experience desirable.
- 10+(BS), 8+(MS), or 0+(Ph.D) years of experience
- Experienced in multi-gram synthesis, natural product total synthesis and reaction optimization.
- Demonstrate the ability to resolve key project hurdles and assumptions by effectively utilizing available information and technical expertise.
- Effective writer and communicator of research or other regulatory materials.
- Strong desire to collaborate and work in a highly dynamic team setting (All for One Abbvie)
- Excellent synthetic chemistry skills
Key Leadership Competencies:
- Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance
- Learns fast, grasps the "essence” and can change course quickly where indicated
- Raises the bar and is never satisfied with the status quo.Creates a learning environment, open to suggestions and experimentation for improvement
- Embraces the ideas of others, nurtures innovation and manages innovation to reality
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Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.