Lead Scientist - Molecular Analysis

Monrovia, California
Apr 08, 2021
Required Education
Position Type
Full time

Xencor is an innovative, clinical-stage biotechnology company located in the Los Angeles area (near Pasadena) and in San Diego. We use our pioneering XmAb® technology to discover and develop better biotherapeutics – antibodies and other proteins with improved function – with the goal of improving patient outcomes and quality of life, and we have an excellent opportunity for a Lead Scientist with Molecular Analysis experience to join our team.

Our protein engineering capabilities and the modular nature of our technology allow us to quickly identify and create new platforms and drug candidates for potential development. We are developing a broad portfolio enabled by the rapid expansion of our bispecific technologies, and nine XmAb bispecific antibodies and cytokines are in clinical testing. We also leverage our many XmAb technologies by engaging in multiple collaborations with leading global biopharmaceutical companies, including Novartis, Amgen and Genentech, among others. Including our partners, over a dozen XmAb drug candidates are advancing through clinical development, and the first antibody that incorporates an XmAb technology has been approved for commercial marketing worldwide.

Our employees are the most important factor in our success and we have assembled a highly talented group from diverse backgrounds and disciplines to execute our business plan and shape our future. Xencor employees value new ideas and flexibility and demand from each other scientific rigor, a passion for innovation, and a willingness to take risks


  • Antibody thermostability characterization and data fitting (DSF, DSC, DLS)
  • Support the antibody discovery and engineering processes at Xencor through real-time binding characterization (SPR, BLI)
  • Communicate results through detailed record keeping, summary reports and presentations
  • Instrument maintenance and other general lab duties


  • Ph.D. in Biochemistry, Biophysics or related field is required.
  • 5+ years relevant hands-on experience required.
  • Previous experience in a biotech environment is desired.
  • Previous management experience is a strong plus
  • Hands on experience with design and data fitting of thermostability assays and real-time binding assays including DSF, DSC, DLS, SPR, BLI.
  • Hands on experience with ELISA or other high-throughput plate-based binding/activity assays
  • Experience with high throughput liquid handling and automation is a plus
  • Excellent time management, record keeping and organizational skills
  • Ability to work well in a multidisciplinary team.
  • Self-Motivated, strong inter-personal and communication skills.
  • Ability to work in a dynamic and fast-paced environment.

We strive to create an environment that will challenge, motivate, and reward our employees for meeting the changing demands of creating breakthrough therapeutics. Xencor has a highly collaborative structure that integrates co-workers with different skill sets into teams for product and technology development.  With an emphasis on attaining the best and most highly qualified candidates in their respective fields, we offer a competitive salary & benefits package. 

Physical Demands:
The physical demands described are representative of those that must be met by an employee to successfully perform the primary functions of this position.

The physical demands of the office are normally association with extended amounts of time sitting and using office equipment, including a computer, keyboard and mouse, which can cause muscle strain. While performing the duties of this job, the employee is frequently required to stand, walk and sit. Periodic light lifting of supplies and materials may apply. Work is performed in an office environment.

 Americans with Disabilities Act (ADA) Statement

The Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon your request as required to comply with applicable laws. If you have a disability and require assistance in this application process, please contact HR@xencor.com.

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential functions.

Equal Employment Opportunity (EEO) Statement

The Company is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender or gender identity, national origin, disability status, protected veteran status or any other characteristic protected by state or federal law.

Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services and or resumes in no way creates an obligation or duty by Xencor, implied or otherwise.