Senior Research Associate/Principal Research Associate, Analytical Development

Apr 06, 2021
Required Education
Masters Degree/MBA
Position Type
Full time

Sana Biotechnology is looking for a highly-motivated individual to join a dynamic, rapidly growing, and collaborative team in the Analytical Development Group. This individual will be a part of the forefront of gene therapy approaches utilizing a novel biological platform, and he/she will support analytical characterization of viral vectors for in-vitro research-based experiments. The candidate will execute assay development activities and work closely with our automation team to increase assay throughput, decrease hands on time, and reduce assay variability. The position represents an excellent opportunity for career development, working closely with experienced cell and gene therapy scientists in a highly collaborative environment.


As a member of the analytical development team, the individual will contribute to the development of Sana's scalable vector manufacturing process platforms through:
  • Developing, optimizing and executing robust and reproducible assays in support of both discovery research and pre-clinical development
  • Utilizing and developing methods on liquid handlers (e.g. Hamilton) to support upstream and downstream process development teams
  • Act as an automation SME within the analytical development team by transferring existing methods to automated platforms and working closely with automation team
  • Execute assays for vector characterization, such as functional titer, physical particle counts, particle aggregation, and infectivity
  • Generating and maintaining various cell lines used by gene therapy process development
  • Implementing superb documentation of procedures and experiments to support tech transfer
  • Excellent communication, documentation, and presentation skills
  • The candidate should be a team player, highly organized and demonstrate curiosity and scientific rigor with excellent problem-solving skills
  • Ability to engage in crucial conversations - providing and receiving feedback
  • Contributing to and being a part of Sana's mission and culture


Basic Qualifications
  • If a PRA: Bachelor's. in molecular biology, biochemistry, protein chemistry, virology or related discipline plus 6 yrs or MS w 4+ yrs or equivalent combination of education and work experience
  • If an SRA: Bachelor's plus 4 yrs or MS w 1-2 yrs or equivalent combination of education and work experience
  • Prior experience in development and execution of assays to characterize and measure proteins and DNA using a variety of methodologies including flow cytometry, qPCR, ddPCR, electrophoresis, ELISA, and imaging
  • Experience with adherent and/or suspension mammalian cell culture, such as CHO, HEK293, or similar cell lines
  • Excellent bench skills with attention to detail and high standards for data integrity and quality
  • Able to critically analyze data and troubleshoot methods and equipment
  • The candidate should be a team player, highly organized with excellent communication skills, and demonstrate curiosity, scientific rigor and excellent problem-solving skills
  • Ability to work in a high-paced team environment and meet deadlines
  • Ability to engage in crucial conversations - providing and receiving feedback

Preferred Qualifications
  • Experience with liquid handler automation platforms (e.g. Hamilton Vantage, Integra, Tecan)
  • Experience will cell-based viral titration assays (e.g. flow cytometry, PCR, ELISA)
  • Experience with viral vector systems, production and/or purification
  • Familiarity with GxP principles and regulations as demonstrated by technology transfer to GxP manufacturing, GxP clinical manufacturing, or significant laboratory support of IND/BLA submissions

  • Flexibility to work some evenings or weekends in support of cell culture processing
  • Ability to travel


Ability to perform assays, standard cell culture in a development lab.