Senior Process Engineer, AAV Process Development

Location
Cambridge, MA, United States
Posted
Apr 03, 2021
Ref
L401
Hotbed
Genetown
Required Education
Other
Position Type
Full time
Our Mission: Developing curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.

Job Description:

Intellia is seeking a skilled and motivated Senior Process Engineer to support AAV clinical scale process development and technical transfer in the Technical Operations organization. The ideal applicant will be experienced and capable in HEK suspension culture and transfection optimization for AAV production. The position requires development, optimization and scale up of AAV production in bioreactors as well as a good understanding of viral production analytics and purification technologies. Experience with documentation and technical transfer to GMP manufacturing is highly desirable. Team work, versatility, and strong problem solving/analytical skills are required.

Responsibilities:
  • HEK293 stir tank bioreactor process development and transfection optimization.
  • Develop and perform pre-clinical scale up production processes based on QbD.
  • Develop SOPs, establish critical process parameters and lead technology transfers to CROs and strategic partners.
  • Provide expertise and guidance in clinical AAV production, development and innovation across the organization.
  • Communicate development results and production schedules with internal teams.
  • Operate and maintain bioreactors and multiple laboratory instruments.
  • Cell culture maintenance and analysis.


Qualifications:
  • Bachelor's Degree in Biochemical Engineering, Molecular Biology, or Virology with at least 8 years of hands on industrial experience, or MS with 6+ years of industry experience.
  • Experience with HEK suspension AAV production and characterization.
  • Proficiency with operation and process optimization in stir tank bioreactors and relevant cell culture analytical techniques.
  • Experience in bioreactor cell culture and purification process development scale up for GMP production.
  • Experience with viral vector analysis is a plus (e.g. CE-SDS, ddPCR, ELISA).
  • Effective inter-department coordination to meet project goals and timelines.
  • Organized, detail-oriented, and a self-starter who continuously seeks innovative solutions.
  • Excellent verbal and written communication skills.


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EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.