Scientist II, Translational Medicine

Location
San Francisco, CA, United States
Posted
Apr 03, 2021
Ref
803377529
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
Zai Lab is seeking a Scientist who will join our Translational Medicine group and contribute to building pre-clinical translational hypotheses to guide patient selection and drug combinations with Zai's clinical pipeline. The incumbent will play a role in supporting development of pre-clinical models and biomarker discovery for our clinical pipelines.
This position is located in Menlo Park, CA and reports to our Principal Scientist, Translational Medicine.

Responsibilities:
- Contribute to positioning our cancer therapeutics in right patient selection based on pre-clinical translational hypotheses
- Support development of pre-clinical models and biomarker discovery to establish best patient selection strategy for our clinical trials
- Support Translational Medicine efforts for the large/small molecule pipelines and Zai's clinical assets
- Perform laboratory bench work with minimal supervision and present the results/findings internally and externally
- Perform routine assays (luminescence/fluorescence assay, qPCR, ELISA, cloning, cytotoxicity assay, western blot, immune staining, confocal microscope, gene knockdown/knockout, flow cytometer, cell culture, gene cloning, gene delivery with lenti/retro virus)
- Process human biological samples such as PBMC and perform ADCC, CDC, ADCP assay
- Maintain/update sample/cell database
- Analyze data from experiments and present the data at a meeting

Qualifications:
- PhD in immunology and/or oncology with a minimum of 0-2 years' relevant post-graduate experience in immunology and/or oncology, or MS with a minimum of 8-10 years' experience in immunology and/or oncology
- Broad training/experience in Molecular/Cell Biology including but not limited to cell culture, DNA/RNA extraction, PCR/qPCR, ELISA, confocal microscope, cloning, and primary cell isolation/culture, immune cell differentiation/activation/co-culture is required
- Experience in the field of immunology and/or oncology is required, including hands-on experience with functional characterization of large/small molecules in vitro/ex vivo
- Proficiency in multi-color flow cytometer is required
- Experience in a live cell imaging using florescence/confocal microscope is a huge plus
- Experience with human biological samples such as PBMC to perform ADCC, CDC, ADCP assay is a huge plus
- Knowledge of tumor microenvironment, immune-oncology, human immunology, in vivo animal model, biomarker, RNAseq, histology, immunohistochemistry is highly desirable
- Demonstrated success in designing, conducting, and analyzing data with minimal supervision, as evidenced by a robust track record of productivity with publications in top-tier journals
- Strong communication and collaboration skills, and capability to conduct research in fast-paced, cross-functional team environment
- Ability to interpret data clearly and concisely both verbally and visually in presentations
- High integrity and desire to discover and develop transformational medicines for patients
- Strong interpersonal ability to collaboratively work in a cross-functional team setting

If you are interested in this position, please send an email with your resume to talent_us@zailaboratory.com