Senior Research Associate - Bioanalytical Sciences - Molecular Biology

Location
Cambridge
Posted
Apr 02, 2021
Ref
5044436002
Required Education
Other
Position Type
Full time
JOB PURPOSE

Sana Biotechnology is involved in developing gene and cell therapeutics for the treatment of a broad range of diseases and conditions. Sana Biotechnology is looking to expand our team with hard-working individuals who believe in the potential of cells as engineered medicines, have the vision to do creative things, and the determination to execute that vision. As a member of the Development Sciences, Bioanalytical Sciences group, you will work within a highly dynamic and cross-functional environment on projects of diverse scope and across multiple therapeutic areas. To accelerate the development of transformative medicines, we seek a Senior Research Associate to build essential platform capabilities as well as develop and implement functional assays to support bioanalytic genomic and transcriptomic assays, IND enabling studies and work with CROs. The Senior Research Associate will perform in genomic and transcriptomic analysis of lead gene and cell therapy candidates in complex pharmacological and clinically relevant models. He/She will have experience in ddPCR, RT-PCR, NGS and other related analytical platforms. The successful candidate will have demonstrated technical proficiency, exhibit scientific rigor and independent thought as well as the ability to thrive in a team-oriented environment.

DUTIES AND RESPONSIBILITIES
  • Uses professional concepts in accordance with company objectives to solve problems in creative and effective ways.
  • Develop and perform DNA/RNA isolation from different cell types and organs for in vivo studies.
  • Work with various types of immune cells
  • Establish and qualify RT-PCR and ddPCR assays for different candidate targets
  • Establish and qualify NGS methods that support IND enabling studies
  • Work with CROs on development and qualification of molecular biology methods
  • Independently plan, coordinate and execute experiments
  • Independently and under the supervision of Senior Scientist and other colleagues work to analyze and interpret experimental results
  • Makes detailed observations, document experimental methods in a well-maintained laboratory notebook
  • Present results at team meetings
  • Facilitate discussion with other team members as necessary to ensure the completion of the team's projects
  • Comply with standard laboratory practices and company policies.

Basic Qualifications

Master's degree or Bachelor's degree with 3-5+ years of laboratory experience in an academic or industry setting and proven proficiency performing independent research.
  • Proven extensive hands-on experience in PCR, cloning, RT-PCR, qPCR
  • Experience in culturing mammalian cell lines with demonstrated competence in sterile cell culture technique and standard laboratory procedures
  • Experience working with in vivo and in vitro models of disease
  • Ability to proactively engage groups with diverse functions within a highly matrixed organization.
  • Excellent oral and written communication skills, attention to detail and data quality, and experience working on cross-functional teams
  • Technical proficiency, scientific creativity, independent thought and ability to actively communicate with scientists throughout the organization

Preferred Qualifications
  • Industry experience, preferentially in BioA environment
  • Experience with ddPCR
  • Experience with NGS platforms
  • Experience with high-throughput and automatic platforms is a plus
  • Experience with general molecular biology methods (Western, Northern, PCR, cloning, in situ RNA hybridization, cell culture)
  • Ability to communicate and lead change
  • Ability to work in a fast-paced, dynamic environment