Scientist, Antibody Discovery

New York, NY, USA
Apr 01, 2021
Required Education
Position Type
Full time
Company Description:

Molecular Templates (MTEM) is a publicly traded, clinical-stage oncology company focused on the discovery and development of differentiated, targeted, biologic therapeutics. The company's proprietary biologic drug platform technology, referred to as engineered toxin bodies (ETBs), provides a differentiated mechanism of action that may address some of the limitations associated with currently available cancer therapeutics. ETBs utilize a genetically engineered form of Shiga-like Toxin A subunit (SLTA), a ribosome inactivating bacterial protein genetically fused to an antibody binding domain (scFv or VHH), that can be targeted to specifically destroy cancer cells. MTEM has three drugs in the clinic and partnerships with Takeda, Vertex, and Bristol Myers Squibb. For more information, please visit MTEM's website at

Position Overview:

MTEM is seeking a highly motivated individual to help build an antibody discovery group. This hands-on position involves generation and screening of antibodies to be used in the company's ETB scaffold for the development of novel therapeutics. The Scientist will join a team of scientists to support therapeutic antibody discovery programs which focus on cancer. This position requires experience with phage display library construction and panning, antibody screening, expression, and optimization. This role will be located onsite in our Manhattan, NY office (Financial District).

Job Responsibilities:
  • Designs and executes phage display library selections for lead identification of antibodies against challenging targets
  • Builds and validates immune phage display libraries
  • Performs high throughput screening of phage panning output
  • Analyzes antibody sequence data (Sanger and/or NGS)
  • Keeps a detailed and well-organized laboratory notebook
  • Presents data at group meetings
  • Stays current with literature and emerging trends in the discipline
  • Performs other related duties as assigned

  • PhD in Immunology, Microbiology, Biochemistry or related field
  • 2+ years of experience in an antibody discovery environment or
  • Master's Degree and a minimum of 4 years of experience in antibody generation in an academic laboratory, or in the pharmaceutical and/or biotechnology industry
  • Demonstrated successful track record with phage display library construction and panning
  • Hands-on experience with whole cell panning techniques
  • Working knowledge of high-throughput phage panning processes (e.g. semi-automated panning on the Kingfisher system and/or colony picking and sample processing on a QPix system)
  • Proficiency in molecular biology techniques (PCR, cloning, primer design, plasmid preparation, etc.)
  • Use of DNA sequence analysis/editing using tools such as Geneious or DNAStar
  • Handling and manipulation of bacterial cultures
  • Enzyme-linked immunosorbent assay (ELISA) development
  • Experience with affinity maturation via phage display strongly desired
  • Experience with B cell cloning a plus
  • Ability to work on multiple projects in parallel to deliver results in rapid timeframes
  • Ability to work independently in a dynamic environment
  • Critical thinking, prioritization of tasks, attention to detail and troubleshooting
  • Creativity in approaches to complex problems and desire to expand technical skillset
  • Timely delivery of team goals and ability to build productive relationships with colleagues across MTEM's R&D department

Reporting Structure:

This position currently has no supervisory responsibilities. This position reports to the Director, Antibody Discovery.

Molecular Templates, Inc. is an Equal Opportunity Employer and offers competitive salaries and benefits.

Molecular Templates Inc