Research Associate, Cellular Therapy

Cambridge, MA
Apr 01, 2021
Required Education
Bachelors Degree
Position Type
Full time


Obsidian Therapeutics is pioneering the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases.  Obsidian’s programs apply our CytoDriveTM technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety. 


Our Opportunity…


We’re looking for a motivated, flexible, collaborative Research Associate to contribute to preclinical research on engineered cell therapy programs.  As part of our Cell Therapy group you will be a vital part of a highly collaborative and skilled team working to achieve Obsidian’s vision by translating innovative science into medical breakthroughs for patients.


This is a unique opportunity to be a scientific contributor in a well-funded early-stage company with blue chip investors, field-leading advisors, and a highly experienced team. You will help us build a dynamic, innovative, passionate, collaborative, and successful organization focused on delivering transformative therapies in areas of greatest clinical need.


Located in the heart of Cambridge, we’re proud of our diverse talented team and committed to cultivating an environment of inclusion where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work.  We offer competitive salary and benefits, and potential for employee ownership through stock options. Apply to

You Will…

  • Make technical and intellectual contributions to projects as part of a collaborative team
  • Work with team leaders to design, develop and apply cell-based immune assays, including engineering of human T cells.
  • Isolate primary immune cells from human blood/tissue and conduct ex vivo engineering, differentiation, and characterization by immunophenotyping and functional readouts
  • Perform ex vivo analysis of samples from in vivo adoptive cell transfer studies
  • Execute carefully planned bench and cell culture experiments, troubleshoot assays, discuss data, and communicate findings/present results at internal meetings
  • Gain the technical and analytical skills needed for cell therapy research and development, including but not limited to: immunophenotyping by multi-parameter flow cytometry, high throughput protein quantitation, primary cell expansion, viral-engineered cell


You Bring…

Core Qualifications

  • BS in biology, biomedical engineering, immunology or biomedical sciences (job title may be adjusted to Sr. RA for those who bring applied experience and advanced capabilities)
  • Ability to quickly learn and adapt to fast paced, rapidly changing start-up environment
  • Familiarity with immunology and cell culture methods including T/NK cell genetic engineering, multi-parameter flow cytometry, cytotoxicity assays, or cytokine quantitation
  • High motivation, and enthusiasm to learn scientific rigor in the execution, analysis, and troubleshooting of experiments
  • Strong communication skills and a highly collaborative work style
  • Ability to work independently and within teams to meet deadlines in a fast-paced, rapidly developing environment, prioritize work across multiple projects, and adapt to changes in order to fulfill our mission
  • Strong record-keeping, time-management and organization skills, with an ability to manage multiple tasks in parallel
  • Authorized to work in the US at the time of application


Bonus Qualifications

  • 2+ yrs experience in a biology/immunology/biomedical research environment (job title may adjust to Sr. RA depending on experience and capabilities)
  • Experience with record-keeping in Electronic Notebook (ELN) format
  • Familiarity with data analysis tools like MS-Excel, GraphPad Prism, Flowjo etc.
  • In vitro culture of primary human immune cells
  • Cellular immunotherapy experience