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Scientist I/II, Stem Cell Biology - CNS

Employer
Maze Therapeutics
Location
South San Francisco, CA, United States
Start date
Mar 31, 2021

View more

Discipline
Science/R&D, Biotechnology, Cell Biology
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Biotech Bay

Job Details

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we'll develop for a range of severe diseases.

We are seeking a talented and highly motivated researcher with strong background in neurobiology to develop pluripotent stem cell models for diseases of the CNS. The successful candidate will have deep expertise in developing complex assays using neuronal and glial cultures. Additional experience with CRISPR gene editing, CRISPR screens, and high-throughput biology is preferred. As a core member of the stem cell group, you will work independently on experiments using cutting edge functional genomics and biological methods. This is an exciting interdisciplinary role in a dynamic cross-functional team that will contribute directly to the identification of new targets and the design and validation of novel disease-modifying therapeutics.

Your Role in Navigating the Maze:
  • Establish and scale hiPSC differentiation protocols into various lineages including neurons, astrocytes and microglia
  • Contribute strategically and creatively to in vitro assay design and optimization
  • Develop complex assays for target discovery, target validation, biomarker discovery, and molecular modeling of disease to support drug discovery programs
  • Work alongside the functional genomics team to develop and optimize CRISPR screens in neuronal cells
  • Collaborate closely with other scientists, bioinformations, and computational biologists
  • Present findings and data analysis in research meetings

Your Navigation Tools:
  • Ph.D. in a biological discipline with relevant research experience, or M.S. with 5+ years of relevant experience
  • Strong background in neurobiology
  • Extensive experience in culturing and developing assays in neuronal cells
  • Demonstrated experience in utilizing hESCs/hiPSCs for disease modeling of neurological disorders, preferably in a drug discovery or industry setting
  • Demonstrated experience and expertise in differentiation of hESCs/hiPSCs into neurons and glia
  • Extensive experience with cell-based assay development using wide range of assays including but not limited to ELISA, q-PCR, single-cell RNA seq, flow cytometry, confocal microscopy, and high-content imaging
  • Experience with CRISPR gene editing and pooled/arrayed CRISPR screens is preferred
  • Experience with laboratory automation is a plus
  • Demonstrated record of success with a strong publication record
  • Organized, detail-oriented, excellent record-keeping skills, excellent verbal and written communication skills
  • Ability to work independently and perform well in a team environment

Company

Maze Therapeutics is translating novel genetic insights into lifesaving medicines, through an approach that integrates human genetics and functional genomics. Advances in these areas have enabled us to decode the mysteries of genetic modifiers in a range of severe diseases, which we aim to turn into medicines that mimic protective mutations. 
 
What are genetic modifiers?
 
Despite an understanding of the genetic basis for many diseases, it remains a mystery why some people with a disease-causing mutation never get sick. This is often due to genes elsewhere in our DNA that affect the severity of disease and can provide a natural form of protection.
 
The Maze approach
 
Dramatic advances in human genetics and functional genomics now enable us to decode the mysteries of genetic modifiers in a range of severe diseases. Today, we believe we can systematically identify genetic modifiers and turn these insights into medicines. We have assembled a world-class team to realize this vision, including creative scientific pioneers, experienced company builders and biotech industry leaders.
 
Join us in our pursuit to change lives by translating genetic insights into medicine - view our job postings with the link to the left.

Company info
Website
Location
171 Oyster Point Blvd, Suite 200
South San Francisco
CA
94080
United States

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