Job Title: Principal Scientist, Vaccine Vector Evaluation
Location: Design and Development Lab Brooklyn, New York, USA
The Principal Scientist is a key member of a multidisciplinary research team dedicated to the development and testing of new vaccine candidates based on viral vectors. This position leads the Vector Evaluation group that is involved in several phases of vaccine research including viral vaccine vector production, executing quality assurance testing on vaccine material used in preclinical studies, and processing animal samples and conducting analyses to detect virus. The Principal Scientist oversees a team of researchers as well as works closely with colleagues across the organization and with external partners/collaborators.
- Manage a research group that participates in multiple areas of vaccine research.
- Process infectious animal specimens and detect virus in processed samples using technologies such as reverse-transcription quantitative PCR (RT-qPCR) while working under rigorous conditions to avoid sample contamination.
- Produce vaccine material used in preclinical studies including thorough analyses to ensure its quality using methods including RT-PCR, Western blotting, nucleic acid sequencing, viral plaque assay, and flow virometry.
- Develop and optimize analytical assays to support vaccine quality assurance testing.
- Develop and apply scalable virus purification technologies.
- Manage laboratory operations such as monitoring inventory, ordering supplies and reagents, maintaining safe working conditions, and proper disposal of chemical and biohazardous waste.
- Maintain accurate, thorough, and timely research documentation.
- Develop operating procedures.
- Oversee data analysis and database management.
- Prepare figures and text for scientific manuscripts, internal and external research reports, and presentations.
- Present at internal and external scientific meetings.
- Create and manage technical transfer of assays and SOPs to external CMOs/CROs.
Education and Work Experience:
- Master’s Degree in biological sciences or chemistry is required. PhD is highly desirable.
- More than 10 years of post-graduation work experience in a research laboratory is required.
Qualifications and Skills:
- Prior managerial experience is required.
- Experience working with samples from animals and determining virus loads is required.
- Experience working with infectious agents, nucleic acid sequencing, RT-qPCR technology, and direct involvement with animal research is required.
- Experience working under laboratory conditions that prevent cross-contamination of biological samples is required.
- Experience with cell culture and virus propagation is required.
- A successful record of manuscript composition and publication is required.
- Excellent written and verbal communication skills is required.
- Experience with filtration-based virus purification technology is highly desirable.
- Knowledge of protein production and purification methods also is highly desirable.
Disclaimer: Nothing in this job description restricts management's right to assign or reassign duties and responsibilities to this job at any time. The above statements are intended to describe the general nature and level of work being performed by individuals assigned to this position. They are not intended to be an exhaustive list of all duties, responsibilities and skills required of personnel so classified. This document does not create an employment contract, implied or otherwise, other than an “at-will” relationship.
IAVI IS AN EQUAL OPPORTUNITY EMPLOYER actively committed to fostering a diverse and inclusive global organization. IAVI believes that diversity and inclusion among our teammates is critical, and we seek to recruit, develop and retain the most talented people from a representative candidate pool. At IAVI, we celebrate the spectrum of colleagues’ experiences and believe that dedication to our mission above all is essential to our success as a scientific global non-profit. IAVI upholds these principles through IAVI’s Global Diversity and Inclusion Committee.
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