Sr. Translational Geneticist - Therapeutic Area Genetics

Location
Tarrytown, NY, United States
Posted
Mar 23, 2021
Ref
23405BR
Discipline
Science/R&D, Genetics
Required Education
Other
Position Type
Full time
We are looking for a computational scientist in our Immune, Respiratory, and Infectious Disease Genetics Therapeutic Area Genetics (TAG) team. You will contribute to the design, execution, and interpretation of genetics studies focusing on autoimmune/immunodeficiency, infectious and respiratory diseases, as part of the TAG team, and to collaborate with the Analytical Genetics and Data Sciences, Sequencing Operations, and Genome Informatics production teams. We conduct large-scale GWAS/ExWAS and refined analyses that enable interpretation of human genetic studies. You will support gene discovery projects, new programs/collaborations, and the overall scientific strategy in genetic and molecular dissection of immunologic, infectious, and respirologic diseases. We are focused to apply human genetics to target discovery, selecting indications for drug programs, and patient/disease stratification through genetic analyses.

In this role, a typical day might include the following:
  • Perform large-scale genetic association studies and refined analysis that will enable interpretation of human genetic analyses.
  • Work with a multidisciplinary genetics team consisting of human genetics scientists, bioinformaticians, statistical geneticists, and other required staff to design, execute, and interpret genetics studies related to immunologic/infectious/respirologic diseases; Collaborate with external partners and internal Regeneron scientists in such efforts.
  • Provide human genetics expertise and consult on projects within other R&D departments at Regeneron, including therapeutic focus area teams, precision medicine, and early and late clinical development teams to introduce human genetics evidence and studies into current research plans and to support drug development efforts
  • Communicate and report study findings and analyses with leadership, administration, and collaborators.
This job might be for you if you:
  • Bring innovative thinking to large-scale genetic studies and analysis.
  • Have a strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward within Regeneron.
  • Are a motivated team player with a desire to pursue genetic discovery in a deadline-oriented, multi-disciplinary environment.
To be considered for this role, you must have a PhD in human genetics, statistical genetics and computational biology with a translational focus. Demonstrated ability to execute human genetics studies delivering novel genetic findings and medically relevant gene discoveries in a team-based environment. Familiarity with statistical genetics and experience executing a breadth of study designs and analyses spanning family and Mendelian studies, population genotype-phenotype association studies. Involvement in or use of large-scale GWAS/WES/WGS data sets such as UK Biobank, GO-ESP, 1,000 Genomes Project, CHARGE consortium, Centers for Mendelian Genomics, ExAC. Familiarity with command line interface, programming languages (e.g. Python, R). Familiarity with statistical genetics tools (e.g. PLINK, SAIGE, REGENIE). Familiarity with and large-scale data platforms (e.g. DataBricks, Scala) and with distributed/cloud computing (AWS). Experience with multiple platforms (chip-based genotyping, WES & WGS, Sanger, custom capture targeted sequencing) as well as other genomic profiling technologies (microarrays, RNASeq), preferred. Experience with genetic analyses involving complex loci (e.g. HLA, 17q21.31) and relevant methods and tools, preferred. Experience with molecular characterization and functional studies geared towards elucidating gene functions and the mechanistic basis for genetic associations, preferred. Familiarity with clinical genetics and various genetic models of disease, preferred.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.