Computational Chemist
- Employer
- Sutro Biopharma, Inc
- Location
- South San Francisco, CA, United States
- Start date
- Mar 19, 2021
View more
- Discipline
- Science/R&D, Chemistry
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- Biotech Bay
Job Details
Sutro Biopharma, Inc. is looking for unique computational chemist that has a solid understanding of Computational Drug Design, Chemical Informatics, data science, computer programing, Machine Learning, and AI.
Responsibilities
- Develop and apply innovative computational approaches to predict biological activity profiles of small molecules using machine learning and free energy approaches
- Generate 3D structural understanding of the mechanism of action for novel ligands using advanced modeling and dynamics simulations
- Initiate drug discovery efforts by proposing novel targets / modalities and executing advanced in silico hit generation methodologies
- Drive compound optimization cycles in multi-objective fashion to explore an expanding chemical universe with the aim to discover superior drug candidates
- Collaborate with interdisciplinary project teams to drive effective decision-making from target identification through candidate nomination
- Keep abreast of scientific literature and interact with internal and external scientists to integrate novel insights into computational approaches for drug discovery
- Create and manage chemical and biological databases
Qualifications
- PhD in computational chemistry, computational biology, computational chemical biology, or related field.
- At least 3 years of work experience applying computational methods to drug discovery. Level of the role to be determined based on experience of the candidate.
- Hands-on experience with proven impact in two or more of the following CADD approaches QSAR/Machine-Learning, Virtual Screening & Triaging, Molecular Dynamics, Free Energy, Multi-Objective Optimization, Generative Chemistry
- Working knowledge of medicinal chemistry, cheminformatics, and structure-based drug discovery
- Computer programming experience (Python, SQL), including experience using machine learning libraries (scikit-learn) and cheminformatics toolkits (RDKit)
- Proven ability to collaborate with others
- Experimental experience is a plus
- 3D structure determination, biophysics assays, medicinal chemistry is a plus
- Experience with MD simulations is a plus
- Cluster computing, cloud computing, web services is a plus
- Working knowledge of MongoDB, PostgreSQL, and chemical cartridges is a plus
Please submit resume for Req. #2068 to jobs@sutrobio.com . Please visit our website at www.sutrobio.com for more information.
Sutro provides a competitive benefits package that includes a choice of health, dental, and vision insurance, life insurance, flexible spending accounts, 401K plan, PTO, ESPP (Employee Stock Purchase Plan) and stock options.
Sutro Biopharma is committed to the diversity of our team and we are committed to Equal Employment Opportunity without regard for race, ethnicity, gender, protected veteran status, disability, sexual orientation, gender identity or religion.
Salaries listed on jobsites may not be representative of salary ranges at Sutro Biopharma.
Please be advised, inquiries or resumes from recruiters will not be accepted.
Company
Sutro Biopharma, Inc., is a clinical-stage company relentlessly focused on the discovery and development of precisely designed cancer therapeutics, transforming what science can do for patients. Sutro’s fit-for-purpose technology, including cell-free XpressCF®, provides the opportunity for broader patient benefit and an improved patient experience. Sutro has multiple clinical stage candidates, including luveltamab tazevibulin, or luvelta, a registrational-stage folate receptor alpha (FolRα)-targeting ADC in clinical studies. A robust pipeline, coupled with high-value collaborations and industry partnerships, validates our continuous product innovation. Sutro is headquartered in South San Francisco. For more information, follow Sutro on social media @Sutrobio, or visit www.sutrobio.com.
Stock Symbol: STRO
- Website
- http://www.sutrobio.com/
- Phone
- 650.881.6500
- Location
-
111 Oyster Point Blvd
South San Francisco
California
94080
United States
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