Clinical Pharmacologist / Pharmacometrician

Location
Newton, MA
Salary
DOE
Posted
Mar 18, 2021
Required Education
Doctorate/PHD/MD
Position Type
Full time

Job Description

Angion Biomedica is seeking an experienced Clinical Pharmacologist / Pharmacometrician with 5 or more years of experience to join a team of highly motivated scientists who are translating fundamental insights into novel therapies. Reporting directly to the Senior Director of Clin Pharm, this is a unique opportunity to take on a role with a broad range of responsibilities.

The Clinical Pharmacologist / Pharmacometrician will assume primary responsibility for providing DMPK and clinical pharmacology expertise to Angion’s discovery and development teams. The successful candidate will have broad subject expertise including clinical pharmacology and pharmacokinetics with experience in design, execution and interpretation of in vitro and in vivo studies and applying this knowledge to the advancement and selection of drug candidates.

Responsibilities:

  •  Provide expert DMPK, clinical pharmacology and pharmacometrics to support compound advancement and evaluation
  • Pharmacometrics: Performs exposure-response, PBPK and Population PK modeling using a variety of softwares, (i.e:  NONMEM, R, Phoenix)
  • Clinical Pharmacology: Conducts the analysis, interpretation and reporting of clinical and non-clinical pharmacokinetic data.  Helps plan, conducts and reports quantitative analyses to select / optimize doses, dosage regimens throughout clinical drug development
  • CRO oversight: deliveres  critical project data through a network of external study providers. In collaboration with project teams, participate in study design, troubleshooting, data analysis and interpretation, Reviews study reports,
  • DMPK: Utilize animal models, define efficacy, pharmacodynamics and translational principles for selection of development candidate moleculesd
  • Translational and Biomarker studies: Facilitate project transitions to Clinical Development in close collaboration with discovery, translational and clinical scientists
  • Regulatory: Manage the preparation and/or presentation of nonclinical pharmacology sections of external documents (e.g. Investigator’s Brochure, IND/CTA, PIP, CTD, etc.)
  • Flexibility: Must be able to contribute to a portfolio of projects spanning early and late preclinical discovery, translational medicine, and clinical development
  • Communication: Play a key role in representing data, interpretations and nonclinical plans for molecules in our pipeline to external parties