Sr. Candidate Process Development Engineer (Upstream)

Location
Redwood City, CA
Posted
Mar 18, 2021
Hotbed
Biotech Bay
Required Education
Associate Degree
Position Type
Full time
Adverum is looking for a Sr. Candidate Process Development Engineer to join our team in our Redwood City office. This position will lead the Candidate Process Development Upstream group in activities encompassing continued development, characterization and manufacturing of novel AAV vectors for both our rare disease and ophthalmology programs.
What you'll do:
  • Identify and lead efforts to evaluate process changes with the goal of optimizing the existing AAV manufacturing process to enhance robustness, scale-ability, and/or yield
  • Supervise a team of engineers in the design and implementation of upstream bioreactor process scale-up efforts across 3L, 50L and 200L vessels, including but not limited to kLa, transfection optimization, lysis and filtration studies
  • Technical involvement in the planning and manufacturing of AAV based viral vectors for development use encompassing cell thaw to harvest and filtration
  • Author and review technical documentation including batch records, developability assessments, method development reports, process history summaries and technical transfers
  • Follow appropriate laboratory procedures and produce competent and reproducible results to a high technical standard
  • Appropriately analyze data, interpret and present results to cross functional teams, and maintain accurate records with no supervision
  • Ensure safe workplace in compliance with the company and EHS rules and regulations
  • Independently solves complex technical problems of ranging scope
  • Works collaboratively and diligently with own group and broader cross functional team(s) to achieve shared objectives
  • Coordinate and manage day to day activities in the lab in order to adhere to the company’s timelines and goals
  • Routinely mentor junior associates on scientific background and technical aspects of work
  • Represents Adverum at technical presentations and conferences to showcase Adverum’s capabilities at the cutting edge of AAV upstream process development.
  • Other responsibilities may be assigned as needed

About you:
  • MS with 5+ years of industry experience or BS with 8+ years of industry experience with a Biochemical or Chemical Engineering degree
  • Hands on experience with stir-tank bioreactor process scale-up in an industry setting is required
  • Direct experience utilizing DOE software (JMP, DesignExpert) is required
  • Experience drafting SOPs, Batch records, reports, and protocols is required
  • Preference given to candidates with knowledge of PAT and data management systems
  • Proficient in general molecular biology techniques including Western Blot, qPCR, BCA
  • Highly motivated team player with excellent verbal and written communication skills, who is capable of leading by example and exceeds expectations in all aspects of the role
  • People management and/or leadership experience is required



About Us
Adverum is a clinical-stage gene therapy company targeting unmet medical needs in ophthalmology and rare diseases. Adverum develops gene therapy product candidates designed to provide durable efficacy by inducing sustained expression of a therapeutic protein. Adverum’s core capabilities include clinical development, novel vector discovery and in-house manufacturing expertise, specifically in scalable process development, assay development, and current Good Manufacturing Practices quality control.

At Adverum, Inclusion and Diversity are at our core. We believe in the power of being your authentic self.  We strive to create the space which allows for everyone in our Adverum Community to not only feel safe but encouraged to speak, learn from each other, grow in their professions and be the very best versions of themselves no matter what their age, ethnic background, gender, origin, religion or sexual orientation