Senior Research Associate, Bioanalytical Assay Development, eDEV & TM

Cambridge, MA, United States
Mar 11, 2021
Required Education
Position Type
Full time
Why Join Intellia?

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.

We want all of our people to go beyond what is possible. We aren't constrained by typical end rails, and we aren't out to just treat people. We're all in this for something more. We're driven to cure and motivated for change. Just imagine the possibilities of what we can do together.

How you will Achieve More with Intellia:

Intellia is seeking a highly skilled and motivated bioanalytical Senior Research Associate to join our growing team in Early Development & Translational Medicine. Your primary responsibilities will be to execute PCR-based methodologies to investigate, monitor, and quantify oligonucleotides to further the development of in vivo and ex vivo gene editing CRISPR/Cas9-based therapeutics. You will also be responsible for quantification of sgRNA, Cas9 mRNA, AAV vector genes, and transgenes in biological matrices in non-clinical and clinical stages of development.

In this role, you will have an opportunity to collaborate cross-functionally to perform data analysis, review, and communicate findings to both internal and external partners.

  • Conduct experiments independently and in collaboration with colleagues in support of project goals
  • Select appropriate assay platform that serves intended use and evaluate novel methods
  • Execute various in-house bioanalytical PCR-based assays such as qPCR, qRT-PCR, ddPCR, and b-DNA for quantification of DNA and RNA (as part of therapeutics such as LNPs and gene therapies) in biological sample matrices to advance CRISPR/Cas9 therapeutic development
  • Analyze data (independently and in collaboration with teams) for PK, PD, and distribution studies and contribute to data driven decisions and strategies to understand drug efficacy, safety, and mechanism of action
  • Compile assay qualifications, author bioanalytical reports, and communicate timelines and results to internal teams
  • Conduct assay failure investigations for both internal and CRO sample analysis functions
  • Contribute to regulatory documents (such as CTA and IND) to advance drug development


‚Äč If you have exceptional laboratory skills, in depth knowledge of qRT-PCR and Droplet Digital PCR (ddPCR ), and strong communication skills, this job is for you!
  • Bachelor's Degree in Biology, Chemistry, Biochemistry, or a related field with at least 2 years of industry experience OR Master's Degree in Biology, Chemistry, Biochemistry, or a related field
  • Applicants should have exceptional laboratory skills, in depth knowledge of qRT-PCR and Droplet Digital PCR (ddPCR ), and strong communication skills (both written and oral).
  • Experience in selection and optimization of oligonucleotide primers, probes, and quenchers for the quantitation of RNA and DNA
  • Experience in troubleshooting new bioanalytical assays
  • Hands on knowledge of tissue extractions for quantification of drug components and the ability to work with blood and tissue-borne biological samples
  • Ability to independently run bioanalytical assays across programs


EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.