Scientist

Location
Peninsula, SF Bay Area
Posted
Mar 05, 2021
Ref
TLS
Required Education
Doctorate/PHD/MD
Position Type
Full time

*This job is located on the Peninsula*

 

BioPhase Solutions specializes in recruiting top talented professionals for California's Scientific community. We are currently looking for curious and creative Scientists to join a collaborative, high performing team at a growing Bay Area biotechnology company.  *This is a direct hire, FTE role. Not a contract.

 

 

Scientist / Senior Scientist (target validation)

*leveling based on amount of relevant experience

 

SUMMARY

Design and execute experiments for small molecule target validation.

RESPONSIBILITIES

  • Develop clear biological hypotheses for multiple novel target genes, select appropriate assays, then establish and validate their mechanism of action in cell models through genomics (CRISPR, RNAi) and pharmacological tools.
  • Establish and profile new human iPSC-based cell models and cell-based assays suitable for investigating target biology in neurodegenerative diseases.
  • Propose additional mechanisms and disease indications with putative targets and nominate related biological targets through a deep understanding of the literature.
  • Serve as an internal domain expert for top biological mechanisms, disease models, and cell-based assays in the field.
  • Work cross-functionally with computational biologists, neurobiologists, chemists, intellectual property experts, and business development to make strategic target recommendations.
  • Work within collaborations with external partners, academic institutions, CROs and consultants as required.
  • The Senior Scientist position may involve coordination and mentoring of junior technical staff, participate in research planning while working independently on high-priority projects.

 

REQUIREMENTS

  • PhD with 2+ plus years of experience in neuroscience, or related discipline (neurodegeneration experience preferred) 
  • Expertise in neurobiology-related gene function investigation in industry or academia.
  • Previous work leading early discovery programs with novel target identification and validation responsibilities.
  • Complex human disease model (iPSC-derived, primary cell, 3D co-cultures, organoids, etc.) generation and characterization experience.
  • Experience working with genomics, human genetics, and next-generation sequencing datasets, ideally in collaboration with computational teams. Experience with commonly used bioinformatics tools and databases (e.g., R or Python for bioinformatics analyses) is a plus.
  • A willingness to roll up your sleeves and be resourceful.
  • Strategic, “systems-level,” and “outside-the-box” mindset and enjoy understanding how pieces fit together in the larger scientific and competitive landscape.