Scientist, Genome Editing

Brisbane, CA, United States
Feb 28, 2021
Biotech Bay
Required Education
Position Type
Full time
Mammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to democratize disease detection with an easy and affordable point-of-care test that allows real-time and simultaneous detection of multiple conditions. By leveraging its internal research and development and exclusive licensing to Cas12, Cas13 and Cas14, Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in Brisbane, CA, Mammoth Biosciences is co-founded by CRISPR pioneer Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Mayfield, NFX, and 8VC, Decheng and leading individual investors including Brook Byers, Tim Cook, and Jeff Huber. At Mammoth, we are passionate about transforming lives through innovation.


Mammoth is seeking a Scientist with expertise in genome editing in cultured mammalian cells. The ideal candidate will have direct experience developing CRISPR systems; a strong background in genome editing and/or genome modulation in mammalian cells is essential. Candidates must be comfortable collaborating with others and prioritizing time, agendas, and projects to accomplish goals.

    • Initiate, direct, and perform experiments to advance the application of CRISPR systems in mammalian cells
    • Develop and characterize CRISPR systems for genome editing applications
    • Manage direct reports and collaborate with others on the team

    • Ph.D. in relevant field with 3+years relevant experience
    • Strong background in tissue culture, molecular biology and cell engineering
    • Demonstrated experience with CRISPR in mammalian cells

    • Experience with CRISPR screens
    • Experience with NGS to characterize CRISPR editing efficiency and specificity
    • Experience working with primary cells
    • Experience with viral vectors such as AAV
    • Experience with bioinformatic tools to handle large data set
    • Liquid handling automation experience
    • Strong communication, presentation and data analysis skills
    • Highly motivated and detail-oriented individual with the ability to think creatively

    • Company-paid health/vision/dental benefits
    • Unlimited vacation and generous sick time
    • Company-sponsored meals and snacks
    • Wellness, caregiver and ergonomics benefits
    • 401(k) with company matching