Scientist I/II, In Vivo Pharmacology

Cambridge, MA, United States
Feb 23, 2021
Required Education
Position Type
Full time
Magenta Therapeutics is a clinical-stage biotechnology company developing therapeutics to reset the immune system to cure more patients with devastating and life-threatening diseases. This immune reset approach can be applied through stem cell transplant to multiple diseases, including autoimmune diseases, such as multiple sclerosis and systemic sclerosis; blood cancers, such as acute myeloid leukemia; and genetic diseases, such as sickle cell disease.

Magenta's comprehensive approach to precision immune system reset will transform many aspects of the transplant process, aiming to make it safer and more effective. Our culture is fueled by a driven, passionate group of people committed to making a difference, seizing opportunities for maximum impact, and pursuing progress for the patients we seek to serve.

We are seeking a highly motivated scientist to join our in vivo pharmacology team. The successful candidate will be an integral member of a cross-functional team involved in multiple projects focused on developing novel therapeutics to improve stem cell transplantation. The position requires experience working with murine models of hematologic, hematopoietic stem cell transplant, oncology, or autoimmune disease.

You are perfect for this role if you are engaged by and want to be responsible for:
  • Design, plan, execute, interpret and manage in vivo pharmacology studies to evaluate efficacy, pharmacokinetic, pharmacodynamic, tolerability and mechanism of action of antibody drug conjugate (ADC) candidates
  • Perform ex vivo assays to broaden our understanding of how our therapeutic leads affect normal immune function and autoimmune disease
  • Provide leadership as the pharmacology representative on a matrixed program team
  • Analyze and present scientific data, engage colleagues in cross-disciplinary scientific discussion, and stay abreast of relevant scientific literature
  • Manage in vivo pharmacology research in a matrixed environment, and externally with CROs.

We would be thrilled if you brought the following with you:
  • PhD in a relevant scientific discipline or MS/BA with a minimum of 7 years' experience in a drug discovery and development setting required (Sci I); PhD with a minimum of 3 years' experience or MS/BA with a minimum of 10 years' in a drug discovery and development setting required (Sci II).
  • Must be proficient in murine handling, dosing (IV, IP, SC), survival blood collection, and tissue harvesting.
  • Requires expertise working with murine models of transplant, autoimmune, oncology, and/or hematologic disease. Humanized mouse experience is a plus.
  • Experience with multiple molecular techniques (Flow cytometry, ELISA, etc.)
  • Experience in the processes and requirements for molecules from discovery to IND (including writing IND reports, patent applications) is a plus
  • Must be a scientifically motivated self-starter, capable of independently conceiving, conducting, and critically analyzing their own innovative research with minimal supervision
  • Ability to think strategically and execute tactically
  • Excellent verbal and written communication skills, strong presentation skills, and demonstrated ability to manage by influence and problem solve in a highly matrixed organization.
  • Commitment to a high-performance, patient & people-first culture, where there is alignment around a common vision and individuals are supported in their growth path
  • Prior success with research in a hands-on, highly collaborative growth environment the ability to work effectively both independently and as part of multi-disciplinary team in a fast-paced environment
  • Ability to make recommendations to effectively resolve problems or issues, by using sound judgment that is consistent with business standards, practices, policies, procedures and regulations
  • Experience working in cultures where courage, commitment and excellence are the backbone of the leadership profile
  • Deep functional knowledge, coupled with business acumen, personal credibility, and outstanding leadership skills

Successful leaders and contributors within Magenta are:
  • Driven. You will be focused on the achievement of Magenta's mission and major corporate goals.
  • Results-focused. Demonstrated record of exceeding stretch goals, and willing to bring creative problem-solving skills to challenges along the way
  • Intuitive. You will enjoy learning and being involved in the content of our whole business, thriving on a very fast-paced and growing business
  • Collaborative. You will have demonstrated the ability to achieve objectives across complex projects and organizational structures
  • Process-oriented, yet flexible. You will appreciate and be able to create and drive process, while also recognizing when flexibility is needed.
  • Transparent and Articulate. You will have the ability to communicate clearly and concisely with all stakeholders
  • Independent. You will be able to self-organize and operate effectively without significant day-to-day oversight, while staying tightly connected to key leaders and teams across the company
  • A role model for the company's cultural pillars; Courage, Commitment & Excellence

At Magenta, we celebrate our differences. We value the power of a diverse array of folks who bring all of themselves to their work. We embrace cultural, cognitive, social, and professional diversity because we know the only way we're going to make new cures possible is by working together.