Principal Scientist, Process Chemistry

Location
Cambridge, MA, US
Posted
Feb 22, 2021
Ref
1073
Hotbed
Genetown
Required Education
Doctorate/PHD/MD
Position Type
Full time
Overview

Black Diamond Therapeutics is a precision oncology medicine company pioneering the discovery and development of small molecule, tumor-agnostic therapies. Black Diamond targets undrugged mutations in patients with genetically defined cancers for whom limited treatment options currently exist. Black Diamond is built upon a deep understanding of cancer genetics, protein structure and function, and medicinal chemistry. The Company's proprietary technology platform, Mutation-Allostery-Pharmacology, or MAP, platform, is designed to allow Black Diamond to analyze population-level genetic sequencing data to identify oncogenic mutations that promote cancer across tumor types, group these mutations into families and develop a single small molecule therapy in a tumor-agnostic manner that targets a specific family of mutations.

Black Diamond Therapeutics, a clinical stage company, based in Cambridge Massachusetts is looking for an experienced process chemist to lead small molecule chemical process development and manufacturing. This is an exciting technical position within the Technical Operations organization. The principal scientist will be responsible for API process development manufacturing.

Responsibilities
  • Collaborate with internal teams and CDMOs to facilitate transition of drug candidates from Discovery into Development
  • Manage CDMOs for process optimization, cGMP manufacturing, supply of key intermediates and drug substance in support of pre-clinical and clinical programs.
  • Lead the route design, route scouting, process optimization and control of multi-step organic syntheses of small molecules to ensure a scalable and cost-effective synthetic route
  • Oversee salt/polymorph screening to ensure pharmaceutical form and compound properties are appropriate for development
  • Proactively work with internal teams and manage CDMOs with regard to scope, timelines, and deliverables
  • Author and review technical and GMP documents, scientific manuscripts, CMC-regulatory documents for regulatory filings and patent applications

Qualifications
  • Advanced degree in synthetic organic chemistry, Ph.D. preferred, with 7+ years in pharmaceutical industry
  • Sound knowledge of synthetic organic chemistry principles
  • Experience in chemical process research, development, scale-up and manufacturing
  • Experience and knowledge of GMP compliance, and relevant ICH quality guidelines
  • Ability to independently plan, organize and manage multiple projects simultaneously
  • Enjoys working in a fast-paced small company environment
  • Up to 20% business travel expected


The physical demands described here are representative of those that must be met by an employee to successfully perform he essential functions of this job.

While performing the duties of this job, the employee is occasionally required to stand; walk; sit; used hands to fingers, handle, or feel objects, tools, or controls; reach with hands and arms; climb be stairs; talk or hear. The employee must occasionally lift or move office products and supplies, up to 20 lbs.

Black Diamond Therapeutics is an equal opportunity employer and welcomes and encourages all applications. Diversity and inclusion are important core values and will encourage our creativity and growth as a company. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.