Principal Research Scientist II/ Senior Principal Research Scientist, DNA Encoded Libraries (DEL) Le

Lake County, IL, United States
Feb 20, 2021
Required Education
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

AbbVie is seeking a highly motivated and experienced leader to join our centralized Drug Discovery Science and Technology (DDST) organization as the lead of our internal DNA Encoded Library (DEL) platform. The successful candidate will be working in a cross functional team to continually enhance internal DEL capabilities and infrastructure as well as oversee our DEL screening activities in support of targets across discovery. The applicant should have extensive experience in DEL technology and a strong track record in successfully applying the DEL platform for hit generation against different target classes in addition to a solid understanding of DNA encoded library selection, protein sciences, biophysics and enzymology. The candidate should be able to work effectively in a cross disciplinary team environment and will manage multiple projects simultaneously in a dynamic and rapidly evolving project landscape.

Key Responsibilities:
  • Lead a multidisciplinary team to enhance DEL screening processes and infrastructure
  • Design and implement project-specific screening strategies with therapy area partners
  • Align hit generation strategies with key project needs as key member of early drug discovery programs
  • Align with protein biochemistry, biophysics, screening teams, project teams, and chemistry teams for hit follow-up
  • Build internal platform learnings through active leadership of new methods development for DEL screening/selection and library design/enhancement
  • Maintain knowledge of current scientific literature and methods on DEL and other screening platforms. Contribute ideas and adopt novel technologies to improve research methodologies
  • Champion innovation and generate new research strategies to effectively address project needs



Position will be hired based on level of experience.
  • PhD in Biochemistry, Biophysics, Chemistry, or related field with typically 8-10+ years of relevant academic and/or pharmaceutical industry experience
  • Extensive hands-on experience in DEL selection and a strong track record in successfully applying DEL platform for hit generation
  • Highly skilled in protein handling and extensive experience in different biochemical and biophysical methods for protein characterization
  • Platform expertise beyond selection sciences (i.e. library construction, informatics, and/or deconvolution) required
  • Excellent problem-solving skills, capable of finding innovative ways to overcome issues
  • Strong communication skills and the ability to contribute in a multidisciplinary environment are essential
  • Experience in leading teams/collaborations and ability to manage several projects simultaneously in a dynamic environment

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Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.