Scientist/Senior Scientist, Protein Sciences (Biologics Development)

Austin, TX, USA
Feb 20, 2021
Lone Star Bio
Required Education
Masters Degree/MBA
Position Type
Full time
Company Description:

Molecular Templates is a clinical-stage company focused on the discovery and development of targeted biologic therapeutics. Our proprietary drug platform technology, known as engineered toxin bodies, or ETBs, leverages the resident biology of a genetically engineered form of Shiga-like Toxin A subunit to create novel therapies with potent and differentiated mechanisms of action for cancer and other serious diseases. For more information, please visit MTEM's website at

Position Overview:

Molecular Templates is seeking an accomplished and highly-motivated Scientist/Sr Scientist to join the Protein Sciences group as part of the research and development (R&D) team. This position will be focused on the analysis, process development and technology transfer for biological drugs. The Scientist will contribute to the development of new methods, protocols, and technologies, including bioconjugation techniques and analytical characterization of proteins and conjugates. The Scientist is expected to apply structural biology knowledge to optimize therapeutic protein design, work on projects with minimal direct supervision and will be expected to apply good judgment within defined procedures and practices to define appropriate actions. The Scientist may be assigned to work with less experienced RA team members to train and mentor them. In addition, they may be assigned as a project lead on internal R&D projects to drive the forward progress of pipeline candidates at the discretion of the management team and in line with R&D priorities.

Job Responsibilities will include:
  • Plan and execute process development and production in order to support R&D's drug discovery programs
  • Conduct biologics drug design and characterization
  • Develop and optimize analytical methods for biologics characterization
  • Develop and optimize and execute protein purification and conjugation processes
  • Independently designs, executes, and troubleshoots experiments
  • Analyzes data and draws logical conclusions to define further action and effectively communicate to team members and management in a timely manner
  • Maintain knowledge of scientific trends, industry processes and pipeline target literature through readings, conferences and seminars in order to contribute to strategic development of novel ETB platforms
  • Document all procedures in an accurate and timely manner
  • Conduct general laboratory duties, including ordering supplies and maintaining inventory and laboratory equipment as needed
  • May function as a subject matter expert and point of contact for the specific functions/equipment within the department
  • With guidance from manager executes and manages new projects, as needed
  • Exercises good judgment within defined procedures and practices to obtain desired results
  • May interface with various departments and serve as internal consultant, as needed
  • May interface with external CRO or Vendors to deliver on project goals
  • Supports in mentoring and training junior team members at the discretion of the management team
  • Other duties and responsibilities may be assigned by supervisor, as needed

  • Master's degree with 5+ years of relevant laboratory experience; or PhD in Chemistry, Biochemistry or related field with 3+ years of relevant laboratory experience
  • Experience in biopharmaceutical industry, preferred
    • In-depth knowledge of analytical methods for the characterization of therapeutic biologics and/or bioconjugates, including HPLC, UV-Vis, mass spectrometry, required
    • Experience in biophysical characterization of biologics, such as DSC, DSF and DLS, highly preferred
    • Demonstrated technical proficiency in bioconjugation of antibodies or recombinant proteins to small molecule drugs and/or nucleic acids, including process development and troubleshooting, highly preferred
    • In-depth knowledge of structural biology, highly preferred
  • Excellent written and verbal communication skills
  • Excellent problem-solving and analytical skills applied to investigations
  • Excellent project management, time management, and multi-tasking skills
  • Proven ability to design research projects independently and provide thought-leadership
  • Ability to manage competing priorities or projects and meet deadlines
  • Ability to function independently and exercise good judgement, as well as work closely in cross-functional teams to support multiple pre-clinical stage programs
  • Ability to function in a fast-paced, high-growth and team-based work environment

Reporting Structure:

This position may have supervisory responsibilities. This position reports to Director, Protein Sciences

Molecular Templates, Inc. is an Equal Opportunity Employer and offers competitive salaries and benefits.

Molecular Templates Inc