Scientist, Antibody Discovery - Immunotherapy Research

Location
San Francisco Bay Area Peninsula
Salary
Competitive - includes stock.
Posted
Feb 19, 2021
Ref
AD-R&D
Required Education
Masters Degree/MBA
Position Type
Full time

SUMMARY

  • Progressive cell therapy startup seeking a motivated and collaborative PhD to become a key strategic voice within the R&D group.
  • Will contribute towards generating novel CAR T binders for diverse targets by implementing advanced antibody discovery approaches such as novel immunization, selection, and single B cell cloning.
  • Will implement screening processes for CAR binder lead identification for both validation and therapeutic targets for diverse therapeutic indications. 
  • Will bring creativity, independence, and collaboration skills and advanced DOE and lab skills in primary cell culture, hybridoma, cytokine analysis, and cytotoxicity assays to develop more potent platform-cell therapies. 
  • Will join a progressive startup that offers a unique mix of seasoned and supportive leadership, cutting-edge science, exceptional internal-talent, and a collaborative work culture, all of which combine to provide fertile ground for professional growth.

QUALIFICATIONS

  • PhD in immunology or related discipline with 0 to 3 years of relevant academic, post doc, or experience or an MS or BS or  skilled Antibody Engineer or Protein Engineer with several years of equivalent experience..
  • Lab techniques of interest include innovative use of some (but not all) of the following: 
    • antibody discovery approaches in immunization, selection, and single B cell cloning; working with primary cell culture, hybridoma, and cytokine analysis and cytotoxicity assays.
    • data analysis using tools such as Prism, Excel, FlowJo, etc.
    • use of screening processes for CAR binder lead identification applied to either or both validation and therapeutic targets.
  • Additional skills of interest would be use of some but not all of the following:
    • antibody structure function and engineering for further optimization of properties for lead selection;
    • low-based cell screening assays for cell surface binding & activation for binder hit selection;
    • experience with Berkeley Lights Beacon to support identifying binder-properties of interest through single B cell cloning; or
    • immunology research applied to cell-therapy T cell or NK cell biology.
  • Demonstrated creativity & initiative relevant to proposing new approaches and analyses to generate more potent platform-cell products.
  • Creativity, analytical and problem-solving skills, and the initiative to provide a strategic voice in experimental approaches would all be welcome within this highly-collaborative and multi-disciplined research team.
  • Desire to contribute and to build technical and leadership skills in a dynamic, productive, and uniquely collaborative team-focused environment 
  • How to Apply: Please send your CV a) by using the BioSpace link below or b) by emailing your CV directly to info@biotecher.com using job code AD-R&D on your email subject line.