Research Associate / Senior Research Associate, In Vivo Pharmacology

San Diego, CA, United States
Feb 17, 2021
Required Education
Bachelors Degree
Position Type
Full time
Vividion is a privately held biotechnology company based in San Diego that is leveraging an innovative and proprietary chemical proteomics platform to efficiently discover novel drugs in multiple areas including oncology and immunology. We aim to transform the future of human health through the limitless creation of highly selective small molecule medicines that reach unreachable targets. As an early stage startup company, Vividion is looking for energetic and experienced candidates with a desire to work in a fast-paced and dynamic team environment. We believe that the whole team contributes to the overall mission. We succeed as a team, and we grow as a team.

Job Summary:

The successful candidate will provide in vivo support for pre-clinical drug development and discovery efforts. Exact title commensurate with experience.

Responsibilities include, but are not limited to:
  • Execute pharmacokinetic / pharmacodynamic (PK/PD), target engagement, efficacy, or mechanism of action studies to support pre-clinical and discovery programs.
  • Troubleshoot experiments.
  • Administer small molecule compounds to mice, measure endpoints (i.e., tumor volume, body weight) and collect blood/tissue for analysis.
  • Perform in vitro cell culture and cell-based assays measuring target engagement and drug effect(s).
  • Perform ex vivo assays on collected cells and tissues as needed.
  • Work both independently and collaboratively as part of an in vivo pharmacology team.
  • Collect, organize, analyze, and present scientific/technical data internally and in project team meetings.

Experience and education requirements:
  • BS with 5-7 years’ experience or MS with 3-5 years’ experience of in vivo in a biotechnology or pharmaceutical setting. Ideally the degree should be in Cancer Biology, Cancer Immunology, Pharmacology or related field.
  • Rodent dosing routes (PO, IV, IP), blood collection (sub mandibular, terminal cardiac, retro orbital), tumor implantation, necropsy, and tumor/organ collection are required.
  • In vitro cell culture including culture of primary human cancer cells is required.
  • Immuno-oncology experience is very highly desired.
  • Rodent surgery experience is highly desired.
  • Experience with flow cytometry, qPCR, ELISA, Western blot; as well as formalin fixation, paraffin embedding, sectioning, and immunohistochemistry is highly desired.
  • Animal Husbandry, IACUC (including ACUP authorship), and AAALAC experience is highly desired.
  • Candidates must have effective troubleshooting and problem-solving skills and possess excellent oral and written communication skills.
  • Candidates must be a team player, strong individual contributor, flexible, and able to handle multiple tasks and deliver high quality results under tight timelines.

Further Information:

In addition to a competitive compensation package with stock options, Vividion also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, life, disability insurance. Vividion Therapeutics, Inc. is an EEO employer.