2021 Experiential Internship Clinical Pharmacology

About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

Appropriate estimation of cerebrospinal fluid (CSF) penetration of therapeutic monoclonal antibodies (mAbs) is important for modeling target engagement and linking it with efficacy endpoints in various neuroscience indications including Alzheimer's disease, Parkinson's disease, multiple sclerosis, spinal cord injury and stroke. The activities of this clinical pharmacology intern would include conducting systematic literature review for published data on CSF penetration of mAbs and reviewing internal PK and imaging data to compile a comprehensive database with mAb physiochemical characteristics and neuronal injury/disease state specific physiological characteristics. The intern will also help build a R or MATLAB based PBPK model with an end deliverable to investigate effect of various physiochemical properties and disease states on mAb CSF penetration and engagement with disease specific targets.

In addition to the primary assignment, the intern will have the opportunity to learn clinical pharmacology aspects of clinical development by shadowing mentors on various cross functional meetings.

Qualifications

Preferred Qualifications:

• Pharmacokinetics, R or MATLAB proficiency, Systematic Literature Review

Minimum Qualifications:

• Minimum GPA = 3.0/4.0
• Returning to university for at least one semester and graduating within one-year post internship
• Currently enrolled in university, pursuing a PharmD or PhD in Neurobiology, Pharmacy, Pharmaceutical Sciences or Clinical Pharmacology
• Demonstrated leadership skills (i.e. extracurricular activities or projects)
• Must be authorized to work in the US on a permanent basis without requiring sponsorship, students on an F1 visa with CPT may be accommodated

Significant Work Activities
Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)
Travel
No
Job Type
Internship
Schedule
Full-time
Job Level Code
IC
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.