Research Scientist, mRNA Drug Discovery

San Diego, CA, United States
Feb 16, 2021
Biotech Beach
Required Education
Position Type
Full time
Job Description

Position: Research Scientist, mRNA Drug Discovery

Reporting To: Director, Pharmacology

Position Objective

Nitto BioPharma Inc is a biopharmaceutical company focused on the discovery and development of novel RNA-based therapeutics for intractable diseases. We are currently seeking a talented, highly motivated and independent research scientist to join our pharmacology/drug discovery group. The successful candidate is expected to lead the mRNA synthesis and evaluation effects, and actively join mRNA drug discovery research.

Major Job Functions

· Develop mRNA therapeutic concepts

· Design, develop, optimize, and execute laboratory biology processes of mRNA synthesis

· Independently design therapeutic mRNA and synthesize therapeutic mRNA efficiently

· Develop methods and run the assays for purification and determination of the synthesized mRNA

· As a team member, evaluate therapeutic mRNA in in vitro and in vivo models

· Conduct different biochemical/biological assays including RNA extraction & qRT-PCR, ELISA, Western blot, Cytokine assays, Flow cytometry, and others

· Analyze and interpret experimental data, and accurately and timely document experimental progress in laboratory notebooks

· Deliver/present research progress to cross-functional project teams and senior staff

Education and/or Experience

· PhD with 2-3 years of experience in molecular biology, synthetic biology, bioengineering, cell biology, or a related discipline or MS with 5-8 years of working experience

· Extensive experience in molecular cloning, vector construction, in vitro transcription and translation, transfection, and transgene expression

· Strong motivation, independence, and ability to thinking critically and creatively to solve problems

· Proven interpersonal and written/oral communication skills

· Direct experience in therapeutic mRNA design, synthesis and modification is a big plus

***Level of the position is flexible and commensurate based on candidate's experience

Physical Job Requirements:

Office/Lab environment. Lifting to 20 pounds may be required. While performing the duties of this job, the employee is regularly required to use their hands and fingers to operate a computer keyboard, mouse, and telephone keypad or to write, as well as talk and hear. They are required to stand, walk or sit, reach with hands and arms, stoop, kneel, crouch or crawl. Specific vision abilities required by this job include close vision, distance vision, peripheral vision, depth perception and ability to focus.

Disclaimer: This job description reflects management's assignment of essential job duties; and nothing in this herein restricts management's right to assign or reassign duties and responsibilities to this job at any time

Company Description
Nitto BioPharma, Inc. is a clinical stage biopharmaceutical company located in San Diego focused on the discovery and development of novel RNA-based therapeutics for intractable diseases. Nitto BioPharma offers unique RNA drug and its delivery solutions by designing novel biodegradable drug delivery systems with the ability to target specific cells and efficiently deliver the cargo into the cells. Clinical assets include two Phase 2 clinical programs, a first-in-class drug for the treatment of liver fibrosis (with Bristol-Myers Squibb), and idiopathic pulmonary fibrosis, as well as a Phase 1 oncology program to treat non-small cell lung cancer.

Nitto BioPharma's mission is to develop and deliver innovative life-transforming therapies for patients with unmet medical needs. Leveraging the long-standing success and track record of Nitto Denko Corporation (Nitto), Nitto BioPharma has created a new and efficient business unit that allows pharmaceutical products to be brought to market at a fast pace. Our long-term vision and unparalleled, multi-disciplinary team of researchers from all over the globe make Nitto BioPharma a vibrant and exciting work environment.

Nitto BioPharma is a key asset of Nitto. Since its establishment in 1918, Nitto has created over 13,500 products based on its core technologies and has contributed to customers' value creation with innovative ideas. The core of Nitto's life science business consists of contract manufacturing and drug discovery. We offer competitive pay and benefits with generous paid time off.