Principal Scientist I, Immune Oncology Discovery

CA, United States
Feb 15, 2021
Required Education
Bachelors Degree
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica, Venclexta, and Empliciti - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments.

AbbVie's Immune Oncology research group sits within the Oncology Discovery organization and identifies novel assets that restore anti-tumor immunity for treating heme and solid tumors.

Job Description:

As a Principal Scientist l, Immune Oncology Discovery you will identify and lead promising new research opportunities in the myeloid biology area. You will leverage internal and external resources by working closely with teams across multiple locations and teams including development, clinical and other groups to develop AbbVie's Oncology pipeline.

  • Responsible for myeloid target identification and biological molecule development
  • Leading and executing scientific research of early stage immune oncology discovery programs and developing strategy in moving those programs through internal milestones towards IND filing.
  • Develop innovative in vivo/ex vivo/in vitro assays/analyses to interrogate the function of immune and tumor cell populations and their interaction
  • Recognized and sought out as an expert in myeloid biology within the company and possibly externally.
  • Resolving key project hurdles with available information from literature and internal or external experts
  • Generating scientific proposal and maintaining a high level of productivity in the lab
  • Promoting AbbVie scientific reputation through writing reports, making external presentations, and publishing original discovery in peer-reviewed journals.
  • Mentoring/supervising small group of scientists and evaluate the performance of those individuals


  • Position will be filled based on level of experience
  • BS or equivalent education and extensive, typically 14+ years of experience; MS or equivalent education with typically 12+ years of experience; PhD with typically 6+ years of experience in field germane tumor immunology, oncology drug discovery and development
  • 6+ years postdoc/industry experience with track record of scientific accomplishments and delivering high quality clinical candidates, as evidenced by INDs, patents and publications
  • Demonstrated accomplishment as scientific leader in large molecule drug discovery and development, such as fusion protein, monoclonal antibodies, bi-specific molecules, and antibody drug conjugate.
  • Strong capability of doing multicolor flowcytometry analysis, proficiency in performing data clustering with different software and familiar with single cell related technology
  • Excellent skills in conventional immune assays and capability of developing comprehensive culture models containing immune cells and tumor cells
  • Experiences in using various types of in vivo models to test IO therapeutics.
  • Excellent communication skills, both oral and written

**Equal Opportunity Employer Minorities/Women/Veterans/Disabled**

Significant Work Activities
Awkward/forceful/repetitive motions (arms above shoulders, bent wrists, etc.)
Yes, 5 % of the Time
Job Type
Job Level Code
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.