Senior/Principal Scientist, Toxicology

Location
Cambridge, MA, US
Posted
Feb 14, 2021
Ref
1067
Hotbed
Genetown
Required Education
Bachelors Degree
Position Type
Full time
Overview

Black Diamond Therapeutics is a precision oncology medicine company pioneering the discovery and development of small molecule, tumor-agnostic therapies. Black Diamond targets undrugged mutations in patients with genetically defined cancers for whom limited treatment options currently exist. Black Diamond is built upon a deep understanding of cancer genetics, protein structure and function, and medicinal chemistry. The Company's proprietary technology platform, Mutation-Allostery-Pharmacology, or MAP, platform, is designed to allow Black Diamond to analyze population-level genetic sequencing data to identify oncogenic mutations that promote cancer across tumor types, group these mutations into families and develop a single small molecule therapy in a tumor-agnostic manner that targets a specific family of mutations.

Black Diamond is currently seeking a Senior/Principal Scientist, Toxicology. Reporting to the Director of Toxicology, the incumbent will be the nonclinical toxicology lead developing small molecules modulators as precision cancer medicines. We are looking for a consummate team player seeking a collaborative environment in which to grow their career in drug development.

Responsibilities

Key Duties & Responsibilities:
  • In partnership with functional/project leaders, set the toxicology strategy and plans for Black Diamond's programs in late discovery and development. Be the functional area representative for nonclinical toxicology on project teams.
  • Lead the planning, design, conduct and analysis of stand-alone toxicology studies in collaboration with internal cross-functional teams. Work closely with DMPK in the design and integration of nonclinical PK/PD activities, collaborate with the research group in planning and conduct of exploratory and GLP toxicology studies.
  • Oversee activities at CROs including study conduct, data review and protocol development. Coordinate with internal and external team in data review, analysis, and reporting of toxicology data.
  • Author and review nonclinical protocols, study reports and prepare relevant sections of regulatory documents, including INDs, CTAs, IBs, and other regulatory documents.

Qualifications

Qualifications:
  • BS, MS, or Ph.D. with 6-8 + years of experience in the biotech/pharmaceutical industry, with a focus in toxicology, safety pharmacology, or related disciplines. DABT preferred.
  • Previous experience managing nonclinical toxicology programs and, in the design, execution and regulatory reporting of toxicology and safety pharmacology studies is required.
  • Technical depth in toxicology, experience in oncology a plus.
  • Experience conducting toxicology programs through early- and late-stage development.
  • Operational experience and familiarity with the drug discovery and development process, including external regulatory requirements. Well versed in authoring and reviewing relevant sections of regulatory dossiers.
  • Proficient in the management of activities at CROs, and comfortable working in virtual outsourced model.
  • Excellent communication and organizational skills; comfortable navigating complexity and ambiguity in a fast-paced environment interacting with consultants, external vendors, and internal cross-functional global project teams.


Work Environment:

This job operates in a professional office environment. This role routinely uses standard office equipment

Physical Demands:

The physical demands described here are representative of those that must be met by an employee to successfully perform he essential functions of this job.

While performing the duties of this job, the employee is occasionally required to stand; walk; sit; used hands to fingers, handle, or feel objects, tools, or controls; reach with hands and arms; climb be stairs; talk or hear. The employee must occasionally lift or move office products and supplies, up to 20 lbs.

Black Diamond Therapeutics is an equal opportunity employer and welcomes and encourages all applications. Diversity and inclusion are important core values and will encourage our creativity and growth as a company. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.