Downstream Process Development Scientist

Location
Gaithersburg, MD, US
Posted
Feb 11, 2021
Ref
2021-9771
Hotbed
BioCapital
Required Education
Masters Degree/MBA
Position Type
Full time
Overview

We are currently searching for a Downstream Process Development Scientist to provide support to the National Institutes of Health (NIH). This opportunity is full-time with MSC and it is on-site in Gaithersburg, Maryland.

Duties & Responsibilities

  • Lead the execution of strategies for purification process development of clinical vaccine and therapeutic candidates.
  • Process virus vaccines, recombinant proteins and virus-like particles that may be used as clinical vaccine and therapeutic candidates.
  • Perform development experience in recombinant protein purification.
  • Lead a group in the execution of scientific strategies for purification process design, optimization, and scale-up.
  • Perform combinations of column chromatography, TFF/DFF, centrifugation or other purification methods.
  • Provide hands-on scientific support of multiple research and pre-clinical purification projects.
  • Perform various purification studies to specify and characterize purification processes. The purification process may include, but not limited to, centrifugation, continuous centrifugation, DFF, TFF, chromatography or other processes required for each product.
  • Study the process sensitivity with respect to various process variables and their interactions using structured statistically designed experiments using DOE including screening and optimization designs.
  • Perform characterization of the product purity
  • Lead the technology transfer of his/her group's clinical purification processes to the cGMP pilot plant to meet project timelines.


Requirements

  • Ph.D. in Biochemistry, Bioengineering, Life Sciences or a related discipline.
  • Minimum of five (5) years of experience in recombinant protein purification development.
  • Previous work experience in a GMP environment in biotech/pharmaceutical industry.
  • Demonstrated knowledge of maintaining accurate and detailed records.
  • Demonstrated expertise in the following techniques or tools for protein purification and characterization:
  • Column chromatography for protein purification by means of AEX, CEX, affinity, SEC, HIC
  • Column packing and testing
  • AKTA chromatography system
  • Lab scale TFF systems
  • Lab scale nano-filtration systems
  • Qualitative assays including SDS-PAGE and Western Blot
  • UV/Vis spectrophotometer
  • Must be a team player who can effectively work with members from cross-functional departments.
  • Strong oral and written communication skills.
  • Familiarity with computer software including word processing and data evaluation.
  • Knowledge and use of statistical design of experiments (DoE).


Company Description

We are a trusted government partner that blends deep domain expertise with advanced technologies to help our customers solve complex problems that improve, protect, and save lives. As a rapidly growing company, we combine entrepreneurial spirit, customer focus, and an outcomes-based approach to support agency missions in health IT, life sciences, public safety, and grants management.

The Dovel Family of Companies offers employees an opportunity to advance beyond a specific role or contract, we offer a path to develop an enriching career. We believe in empowering a culture of innovation, customer success, and employee growth.

What you'll get...
  • Time Off! Flexible schedules and company paid holidays allow you to take the time you need.
  • Investment in YOU! 401(K) company contributions are yours to keep with no waiting period.
  • Choices! Unique healthcare plans to choose from with options like fertility and orthodontia benefits.
  • Discovery! With our tuition assistance and training programs, we support your career advancement.
  • Tax Savings! Enroll in pre-tax Health or Dependent Care Flexible Spending, HSA with company contributions, parking, and/or transit commuter benefits.
  • Support! Working parents and busy professionals - we've got you covered with a supportive culture, confidential Employee Assistance Program and a membership to Care.com.
  • Perks! Employee discounts, peer recognition programs, company-wide wellness challenges, and fun community events.
  • A Voice! A unique culture where you can influence decisions and have your voice heard.


We are an Equal Opportunity Employer with a commitment to diversity. All individuals, regardless of personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, sexual orientation, gender identity, disability, or veteran status.