Scientist, Protein Purification

Location
Bethesda, MD, US
Posted
Feb 11, 2021
Ref
2021-9814
Hotbed
BioCapital
Required Education
Masters Degree/MBA
Position Type
Full time
Overview

We are currently searching for a Scientist, Protein Purification to provide support to the National Institutes of Health (NIH). This opportunity is a full-time position with MSC, and it is on-site in Bethesda, MD

Duties & Responsibilities

  • Assist and collaborate on the design and development of viral proteins from multiple sources, specifically for use as B cell probes or serological analyses accordingly.
  • Lead purification efforts for production of candidate viral proteins for use in immune screening.
  • Develop high-throughput and automated protein purification methodology, where required.
  • Produce research reagents using either transient expression techniques or by expansion of stable cell lines or pools.
  • Coordinate and work with the program team, to ensure the availability of proteins, and to gather data and understand the process.
  • Liaise and perform experimental quality investigations e.g., antigenicity experiments on protein purification, optimization of cell culture conditions.
  • Participate in project and laboratory meetings, keep current with the literature in the field and help assure the laboratory maintains its state-of-the-art status; publish results and studies in peer reviewed journals.
  • Design, propose, and perform experiments in the area of protein purification process development, capturing and communicating the results in several formats, as well as research groups outside the program.
  • Develop and maintain collegial, collaborative relationships with colleagues in the program research groups and Purification, Analytical, and Manufacturing to ensure that efforts are efficiently translated with other groups #LI-AA1


Requirements

  • Ph.D. in a related discipline or four (4) years of specialized experience plus a Master's degree is equivalent to a Ph.D.
  • Minimum of five (5) years of related experience.
  • Knowledge of viral and vaccine immunology.
  • Expertise in molecular biology and design of expression vectors, transfection techniques, screening of cells expressing recombinant proteins and knowledge of classical purification methods such as ammonium sulfate precipitation.
  • Demonstrated ability to study biomolecular interactions using ELISA as well as the use of labelfree methods such as BioLayer Interferometry and SPR.
  • Familiarity with scientific 2D graphing and statistics software (GraphPad Prism, etc.) and statistical design packages (JMP, etc.).
  • Basic computer skills to include MS Word, Excel, and PowerPoint. Background in biology, chemistry, biochemistry and/or biophysics.
  • Familiarity with GLP or GMP and GCLP


Company Description

We are a trusted government partner that blends deep domain expertise with advanced technologies to help our customers solve complex problems that improve, protect, and save lives. As a rapidly growing company, we combine entrepreneurial spirit, customer focus, and an outcomes-based approach to support agency missions in health IT, life sciences, public safety, and grants management.

The Dovel Family of Companies offers employees an opportunity to advance beyond a specific role or contract, we offer a path to develop an enriching career. We believe in empowering a culture of innovation, customer success, and employee growth.

What you'll get...
  • Time Off! Flexible schedules and company paid holidays allow you to take the time you need.
  • Investment in YOU! 401(K) company contributions are yours to keep with no waiting period.
  • Choices! Unique healthcare plans to choose from with options like fertility and orthodontia benefits.
  • Discovery! With our tuition assistance and training programs, we support your career advancement.
  • Tax Savings! Enroll in pre-tax Health or Dependent Care Flexible Spending, HSA with company contributions, parking, and/or transit commuter benefits.
  • Support! Working parents and busy professionals - we've got you covered with a supportive culture, confidential Employee Assistance Program and a membership to Care.com.
  • Perks! Employee discounts, peer recognition programs, company-wide wellness challenges, and fun community events.
  • A Voice! A unique culture where you can influence decisions and have your voice heard.


We are an Equal Opportunity Employer with a commitment to diversity. All individuals, regardless of personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, sexual orientation, gender identity, disability, or veteran status.