Research Associate III, Gene Circuit Discovery

Thank you for your interest in a career at Senti Biosciences. We are passionate about developing cell therapies with the ability to outsmart cancer and other complex diseases. We find purpose and meaning in knowing that our efforts will soon improve the lives of patients and their families. With science as our foundation and empathy as our key guiding principle, colleagues become friends, managers become mentors, and with time, cancer becomes history.

Senti Bio is seeking a collaborative and passionate Research Associate to join our Gene Circuit Discovery group. The Research Associate will apply expertise in mammalian and immune cell culture (e.g. NK cells, T cells, Macrophages, and/or monocytes) to generate regulated cell and gene therapies. The ideal candidate will be comfortable executing in vitro experiments in mammalian cells including primary immune cells, communicating findings, and collaborating with Senti colleagues to push projects forward in a fast-paced startup environment. Additionally, the successful candidate will value and demonstrate Senti's core employee attributes: empathetic, collaborative, intellectually curious, and intrinsically motivated.

Responsibilities

• Generate viral vectors for gene circuit transduction into multiple mammalian cell types including primary immune cells (e.g NK cells, T cells, Macrophages, and/or monocytes)
• Evaluate gene circuit performance using a variety of in vitro assays including microscopy, multi-color flow cytometry, ELISA, and Luminex
• Collaborate with lead scientist to analyze data and present results to downstream stakeholders
• Document experiments by generating timely records of protocols and data using Senti's electronic lab notebook
• Collaborate with your colleagues at Senti by coordinating with other group members and research teams to troubleshoot problems, develop new assays, and support cross-functional projects

Basic Qualifications

• B.S. or equivalent in immunology, molecular biology, synthetic biology, biotechnology, immunoengineering, bioengineering, cell engineering, or equivalent
• 3+ years of lab experience in academia or industry
• Proficient with mammalian cell culture and sterile technique
• Experience with multi-color flow cytometry experiments
• Desire to be a team player in a fast-paced environment
• Comfortable presenting work to cross-functional groups

Preferred Qualifications

• Comfortable with primary immune cell culture (e.g NK cells, T cells, Macrophages, and/or monocytes)
• Familiar with immunology assays for cell surface markers, cytokines, cytotoxicity and/or migration
• Experience with NGS sample preparation and/or data analysis
• Proficient with lentiviral production and transduction
• Familiarity with FlowJo or similar application, (Prism and Benchling are also a plus)

Salary & Benefits

• Base pay, bonuses, and benefits to be determined based on application qualifications with the aim of being competitive with similar roles in the area
• Significant growth opportunity as the company expands

Senti Bio is the next generation therapeutics company that designs gene circuits and programs cells for tremendous therapeutic value. Our mission is to engineer an entirely new class of medicine that will transform people's lives by curing the most challenging diseases. We are proud to count NEA, 8VC, Amgen Ventures, Pear Ventures, Lux Capital, Menlo Ventures, Allen & Company, Nest.Bio , Omega Funds, Goodman Capital, and LifeForce Capital among our investors. Senti Bio is based in South San Francisco, CA, USA.