Sr. Scientist, Molecular Biomarker Assays

Location
Philadelphia, PA, United States
Posted
Feb 04, 2021
Ref
2388602461
Hotbed
Pharm Country
Required Education
Doctorate/PHD/MD
Position Type
Full time
Position Title: Sr. Scientist, Molecular Biomarker Assays

Position Level: Sr. Scientist

Reports to: Director, Head of Translational Development

Department Name: Early Development - Translational Development

Company Background:

Century Therapeutics is developing novel allogeneic living cell products for oncology that overcome the limitations of current cell therapies. Century's genetically-engineered, universal iPSC-derived immune effector cell products are designed to specifically target hematologic and solid tumor cancers. Our commitment to developing off-the-shelf cell therapies will expand patient access and provide an unparalleled opportunity to advance the course of cancer care.

Century's foundational technology is built on induced pluripotent stem cells (iPSCs) that have unlimited self-renewing capacity. This enables complex cellular engineering to produce controlled cell banks of modified cells that can be expanded and differentiated into desired immune effector cells, which can supply vast amounts of allogeneic, homogeneous therapeutic products. This platform differentiates Century from other approaches that utilize non-renewable donor-derived cells.

Role:

The Century Therapeutics Translational Development team is seeking a Molecular biologist with immune oncology experience who will be responsible to develop, validate and implement, either in-house or at CROs, a suite of clinical biomarker assays for Century's allogeneic NK and T cell studies. The individual in this position will have the exciting opportunity to build core translational bioassay capabilities and SOPs as well as explore innovative assays/ technologies to interrogate clinical trial samples to understand the mechanism of action of the product. The role is expected to be 50-75% lab based.

Responsibilities:
  • Develop & deploy qPCR/ddPCR-based molecular assays for PK monitoring, and for exploratory blood/ tissue biomarker evaluations in clinical specimen
  • Select appropriate platforms/ assays & implement MRD testing in clinical trials in heme malignancies. Includes exploratory approaches such as liquid biopsies.
  • Define & lead appropriate NGS-based exploratory analyses of clinical specimen for elucidating MOA/ mechanisms of resistance. Includes investigating mechanisms of antigen loss/ tumor heterogeneity and iNK/iT profiling.
  • Evaluate best methods to collect clinical samples for various downstream molecular biomarker assays.
  • Establish best practices and SOPs for in-house clinical sample processing & testing, analysis and reporting.
  • Perform selected biomarker assays on clinical trial samples in-house, analyze, interpret and communicate data to management.
  • Define assays for outsourcing and direct appropriate GxP or 'fit-for-purpose' validation at CRO partners & generation of high-quality data.
  • May participate in the evaluation/suitability of novel cutting-edge technologies appropriate for translational studies.
  • Collaborate with research, analytical development, QC, compliance and computational biology teams as appropriate, to achieve the above objectives.


Qualifications: PhD in biological field with 4-6 years of post-doc/industry experience, or MS 10+ years relevant professional experience. Degree/ experience in molecular biology/immunology or related field.

Requirements:
  • Biomarker assay validation experience in an industry setting (or similar experience in an academic environment)
  • Strong experience in molecular methods including qPCR, ddPCR, applications in next-gen sequencing (with understanding of data analysis pipelines)
  • Experience in immune oncology
  • Management of assay development work at CROs/external partners
  • Working knowledge of GxPs
  • Self-starter with the ability to wok in a dynamic startup environment


Preferred Skills:
  • Prior cell therapy experience
  • Experience with human T cell and/or NK cells isolation and profiling
  • Expertise in multicolor flow cytometry
  • Experience with single cell profiling NGS assays (10x is a plus)
  • Experience with high-plex molecular analysis platforms used in translational research such as nanostring, MSD, immune-PCR etc.
  • Strong verbal and written communication skills with experience presenting data to a diverse cross-functional audience


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