Research Associate / Scientist, Antibody Discovery

Location
San Francisco, CA, United States
Posted
Feb 03, 2021
Ref
1284133279
Hotbed
Biotech Bay
Required Education
Masters Degree/MBA
Position Type
Full time
We are seeking a highly motivated individual to join as a Research Associate Scientist/Scientist in the Antibody Discovery team. The successful candidate will contribute to our efforts for the discovery of monoclonal antibodies using hybridoma and single cell B cell technologies. The successful candidate will be expected to work independently to oversee and deliver on projects against a variety of targets.

This position is located in Menlo Park, CA.

Responsibilities:
- Design and execute antibody discovery campaigns to generate monoclonal antibodies using hybridoma and/or B-cell technology platforms, including animal immunization, screening, fusion, and subcloning for therapeutic antibodies
- Evaluate serum titres, harvest spleen and lymph nodes, and perform electrofusions
- Screen and characterize antibodies for binding and functional activity using ELISA, Flow cytometry, biochemical and cell-based assays, and biomolecular interaction technologies such as SPR or BLI
- Maintain, expand, cryopreserve, and clone hybridoma cell lines
- Perform small scale antibody expression and purification of antibodies
- Explore new technologies, opportunities and automation to improve and/or streamline the antibody discovery workflow and process
- Provide regular progress updates to the project teams and help optimize the antibody discovery workflow

Qualifications:
- MS in Molecular Biology, Biochemistry, Immunology or related field with 2+ years industry experience, OR
- BS in Molecular Biology, Biochemistry, Immunology or related field with 5+ years of industry experience with strong prior track record of success
- Hands-on experience with antibody discovery using hybridoma technology/B cell approach
- Hands-on experience with protein-protein interaction using a variety of methods such as ELISA, Flow cytometry, Bio-Layer Interferometry (Octet)
- Hands-on experience with cell biology including mammalian cell culture, transfection and running functional cell-based assays
- Excellent organization and communication skills
- Strong interpersonal and presentation skills
- High attention to detail and initiative, as well as energy
- Self-motivated and collaborative, with excellent time management skills
- Strong team player

Preferred Qualifications:
- Experience with automation and high throughput assay development
- Small animal handling techniques
- Experience with molecular biology techniques

If you are interested in this position, please send an email with your resume to talent_us@zailaboratory.com