Research Associate – Antibody Discovery

94080, South San Francisco
A competitive benefits/ Salary package.
Feb 02, 2021
Required Education
Bachelors Degree
Position Type
Full time

Research Associate – Antibody Discovery

South San Francisco, California
Apeximmune is a preclinical stage biotechnology start-up where we believe in harnessing the power of the immune system to treat and cure cancer. Based in South San Francisco, Apeximmune discovers and pioneers novel therapeutic antibodies that modulate immune cell activity to elicit durable, lasting efficacy in cancer and autoimmune disease. Our team integrates expertise in immunology, tumor cell biology, and protein biochemistry and engineering to provide therapies that can transform patients’ lives.

Apeximmune is seeking an experienced and talented Research Associate to join our therapeutic antibody discovery team. As an early hire, you will contribute to our in-house hybridoma capabilities and play a key role in the discovery, characterization, and development of antibodies for our immuno-oncology therapeutic programs. The position will support our hybridoma campaign efforts including immunization, fusion, and maintaining, expanding, and subcloning hybridoma cell lines. You will also help with antibody screening using various binding and immune cell functional assays.

Key responsibilities include:
• Evaluating serum titers, processing of spleen and lymph nodes, and performing fusions
• Collection of hybridoma supernatants to screen and characterize antibodies for binding and functional activity using ELISA, FACS, and various cell-based assays
• Maintain, expand, cryopreserve, and subclone hybridoma cell lines
• Perform small scale antibody expression and purification
• Explore new technologies, techniques, and approaches to improve the antibody discovery workflow process

Successful candidates will have the following:
• Bachelor’s degree (or above) in biological sciences or a related scientific field is required with 2+ years of industry experience
• Experience in cell culture and strong sterile technique.
• Experience in antibody characterization including binding assays with ELISA and/or FACS.
• Ability to multi-task, problem solve, and work independently in a close team environment
• Strong communication, organization, interpersonal skills, and attention to detail

• Hands on experience with hybridoma technology or antibody discovery platforms
• Experience with methods directly measuring bio-molecular interactions (Biacore, Octet, etc.)
• Experience with small animal handling techniques

If you like the idea of creating new therapies that have a major impact on patients’ lives, of helping a new company rise off the ground, and of being part of a collaborative and talented team where everyone’s voice is valued, then this is the role for you.