Senior Scientist, Downstream Purification

At Alector, our mission is to develop therapies that empower the immune system to cure neurodegeneration. Our team is solely focused on developing cures for some of the most challenging diseases facing our society. We are supported in this mission by experienced and accomplished scientists and board members, leading healthcare investors and some of the most innovative pharma companies.

Would you like to take part in creating new therapies that really make a difference in patients' lives? Do you desire both autonomy and collaboration in taking on scientific challenges that interest you? Would you like to be part of a hardworking team where everyone has a voice?

Use your scientific skills to help us achieve our mission of saving lives by curing neurodegenerative diseases.

As a Purification Senior Scientist for the Alector Biologics Manufacturing team, you will report to the Associate Director and work closely with other scientists in Upstream and Downstream Process Development and manage your own team of 1-2 research associates. Alector is seeking an upbeat candidate with expertise in protein purification with hands-on, in-depth experience purifying monoclonal antibodies, fusion proteins, and bi-specific molecules.

As one of the lead Downstream scientists in the group, you will lead internal PD projects where you will be responsible for: developing multi-step purification processes, liquid formulations, authoring development and tech transfer reports, planning, scheduling, and prioritizing workload to meet company goals. In this role, you will have the opportunity to work cross-functionally across multiple departments including cell culture, discovery, pre-clinical, and research. You will identify and provide support for ongoing programs and your work will be central to Alector’s strategic goals. You will be influential in championing and developing Alector’s culture.

During your first year, your goals will include:

  • Expand in-house Downstream purification process capabilities and take the lead in developing robust processes for large-scale manufacturing of Drug Substance and Drug Product

  • Must have management experience advising one or more employees

  • Cultivate your teams' skills and career development by mentoring them in basic and sophisticated purification techniques, and lab best-practices

  • Participate actively in decision-making process on cross-functional project teams by providing scientific input

  • Be SME lead for technology transfer of processes for large-scale manufacture of Bulk Drug Substance

  • Late Phase III process validation experience a big plus!

  • Advance group capabilities and know-how by identifying and implementing novel technologies

  • Author Process Descriptions, Purification Processes technical reports, Stability Reports and review draft and executed batch records and manufacturing documents

We'd love to hear from you if:

  • BS or MS with 8+ years industry experience or PhD with at least 4+ years of industry experience, with industry experience, preferred (willing to consider more experience for the right candidate)

  • Extensive depth and breath performing, optimizing, and scaling various purification chromatography techniques: Affinity, SEC, IEX, HIC, mixed mode (e.g. CHT, Capto MMC, Capto Adhere)

  • Small and large-scale expertise developing and optimizing process parameters for Tangential Flow Filtration (TFF) and Normal Flow (NF) filtration

  • Hands-on experience running analytical assays for protein characterization using the following techniques: SEC-HPLC, iCEIF, SDS-PAGE, CE-SDS, UV-Vis, LAL

  • In-depth experience using AKTA purification systems and familiarity trouble-shooting, writing methods, and performing routine maintenance

  • Experience with lyophilization of proteins highly desirable

  • Familiar with DoE experimental design and statistical interpretation of data using software (e.g. JMP, Stat-Ease)

  • Proven track record to independently run functional responsibilities

  • Leading and mentoring your team

  • Excellent written and oral interpersonal skills

At Alector, we believe that high-performing teams include people from a wide variety of backgrounds and experiences who can challenge each other’s assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, disability status, or any other characteristics protected under applicable federal, state, or local laws.

Alector is a great place to learn and experiment. If you excel in a dynamic environment where everyone is committed to finding a cure, where you’ll drive growth, this is the role for you. There is no limit to how far you can go with us.


While we’ve focused on what to look forward to during the first year and beyond, Day One is great, too: committed and driven colleagues, a bold and important company goal, state-of-the-art brand-new brightly-lit offices in the heart of the biotech area, competitive compensation and benefits. But these matter only if you’re excited to build and own something great, and take on these challenges with us. Come join us.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.