Scientific Researcher/Senior Scientific Researcher, Biomarker Development (Fibrosis/Immunology)

Description

We are seeking a highly motivated and interactive SR/SSR to join the OMNI Biomarker Development group within Development Sciences. Our group is responsible for developing and implementing biomarker strategies aimed to study the molecular pathways driving disease and to establish the mechanism of action of our therapeutics. We focus on prognostic, predictive and pharmacodynamic biomarkers to enable our vision of “the right drug for the right patient at the right dose”. 

Who You Are

The successful candidate will effectively collaborate with OMNI-BD scientists and scientific managers to identify and implement biomarkers in preclinical models and clinical trials of novel therapeutics, with a focus on fibrosis and immunology indications.

• Evaluate candidate biomarkers in preclinical models; Implement biomarker assays in preclinical studies.
• Evaluate, develop, and optimize clinically feasible biomarker assays; Implement biomarker assays in clinical trials.
• Interrogate large molecular profiling datasets, including scRNA-seq and complex RNA-seq and proteomics experiments to address biomarker questions.
• Keep abreast of new technologies and evaluate novel biomarker assay platforms. 
• Plan, execute, and troubleshoot experiments independently. Interpret results and communicate observations clearly.
• Participate in interdepartmental and external collaborations. 

 
Technical Expertise:

Demonstrated excellence with a broad spectrum of laboratory techniques, such as:

• immunoassays, cell-based assays, and -omic methods.
• Prior experience working with human samples from clinical studies is highly desired.
• Specific expertise in assay development and qualification is preferred.
• Ability to analyze large data sets using bioinformatic software such as R.
• Effective oral/written communication skills. Prior contributions to regulatory documents (INDs, CTAs), presentations at conferences or authorship on manuscripts is desired but not required.
• Ability to organize and independently present work in a clear and effective manner at internal and external meetings.
• Pro-active, independent, creative, flexible and demonstrating scientific curiosity. 

Requirements:

• B.A./B.S. or M.S degree in biochemistry, cell biology, immunology, pharmacology, or a related field.
•  At least 3 years work experience in industry or relevant academic experience. 

Roche is an equal opportunity employer. 
 
Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. 
 
Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society.  We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.  
 
The next step is yours. To apply today, click on the "Apply online" button. 
 
Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.