Senior Scientist, In Vitro Pharmacology

Austin, TX, USA
Jan 22, 2021
Lone Star Bio
Required Education
Masters Degree/MBA
Position Type
Full time
Company Description:

Molecular Templates is a clinical-stage company focused on the discovery and development of targeted biologic therapeutics. Our proprietary drug platform technology, known as engineered toxin bodies, or ETBs, leverages the resident biology of a genetically engineered form of Shiga-like Toxin A subunit to create novel therapies with potent and differentiated mechanisms of action for cancer and other serious diseases. For more information, please visit MTEM's website at

Position Overview:

Molecular Templates is seeking an accomplished and highly-motivated Sr. Scientist to join the In Vitro Pharmacology group as part of the research and development (R&D) team. This position will be primarily lab-based and focused on the execution, development and/or refinement of cell-based assays and systems to characterize novel immunotoxins. The Sr. Scientist will contribute to the strategic design of in vitro and in vivo studies and systems to accelerate candidate selection within the R&D pipeline. The Sr. Scientist is expected to work on projects with minimal direct supervision and will be expected to apply good judgment to procedures and choose appropriate approaches to answer outstanding questions. The Sr. Scientist will work closely with more junior team members to train and mentor them and in task delegation. Sr. Scientists will have leadership opportunities managing R&D projects of a larger scope, including both leading technological advancements to the R&D platform as well as early pipeline project leadership.

Job Responsibilities will include:
  • Function as the technical leader and point-person for specific techniques within the In Vitro Pharmacology department.
  • Based on methods utilized across industry, develop cell-based assays and experimental systems for use at MTEM to interrogate ETB biology. This includes assay development and validation, SOP generation and training.
  • Effectively communicate high-level biological concepts across departments and to leadership teams.
  • Independently design, execute, and troubleshoot experiments to evaluate activity of novel biologics and ETBs
  • Analyze, draw rational conclusions, and synthesize complex data sets for presentation to team members, external partners, and management in a clear and timely manner.
  • Function as a thought leader to support strategic goals and execution of functional group and project team needs.
  • Maintain knowledge of scientific trends, industry processes and pipeline target literature through readings, conferences, and seminars to contribute to strategic development of novel ETB platforms.
  • Document all procedures in an accurate and timely manner.
  • Conduct general laboratory duties, including ordering supplies and maintaining inventory and laboratory equipment as needed.
  • Manage projects of significant scope, delegate responsibilities, and be accountable for project timelines.
  • Exercise judgment in choosing appropriate experimental approach and in selecting methods, techniques, and evaluation criteria for obtaining desired results to drive projects towards defined goals and milestones.
  • Work independently on complex problems in which analysis of situations or data requires an in-depth evaluation of various factors.
  • Independently mentor junior team members and be responsible for direct reports at the discretion of the management team.
  • Interface with various departments and serves as internal consultant, as needed. May interface with external CROs and collaborators to deliver on project goals.
  • Other duties and responsibilities may be assigned by supervisor, as needed.

  • Master's degree with 7+ years of relevant laboratory experience; or PhD in Biochemistry or related field with 5+ years of relevant laboratory experience.
  • Demonstrated, documented (or directly observed) success in technical proficiency, scientific creativity, collaboration with others and independent thought.
  • Experience in industry R&D, required.
  • Experience with mammalian cell culture, cellular pathway analysis, microscopy techniques, and basic flow cytometry, required
  • Experience with in vitro characterization of biologic drugs in an industry setting, required
  • Track record of project leadership in a drug development setting, preferred
  • Excellent written and verbal communication skills
  • Excellent computer skills with knowledge of spreadsheet, word processing and statistical analysis software
  • Excellent problem-solving and analytical skills applied to investigations
  • Excellent project management, time management, and multi-tasking skills
  • Proven ability to design research projects independently and provide thought-leadership
  • Ability to manage competing priorities or projects and meet deadlines
  • Ability to function independently and exercise good judgement, as well as work closely in cross-functional teams to support multiple pre-clinical stage programs
  • Ability to clearly and efficiently document, communicate and present complex data sets
  • Ability to function in a fast-paced, high-growth and team-based work environment

Reporting Structure:

This position may have minimal supervisory responsibilities. This position reports to the Director of In Vitro Pharmacology, R&D.

Molecular Templates, Inc. is an Equal Opportunity Employer and offers competitive salaries and benefits.

Molecular Templates Inc