Research Associate Scientist, Discovery Biology

Location
New York, NY, US
Posted
Jan 21, 2021
Ref
1074
Required Education
Bachelors Degree
Position Type
Full time
Overview

Black Diamond Therapeutics is a precision oncology medicine company pioneering the discovery and development of small molecule, tumor-agnostic therapies. Black Diamond targets undrugged mutations in patients with genetically defined cancers for whom limited treatment options currently exist. Black Diamond is built upon a deep understanding of cancer genetics, protein structure and function, and medicinal chemistry. The Company's proprietary technology platform, Mutation-Allostery-Pharmacology, or MAP, platform, is designed to allow Black Diamond to analyze population-level genetic sequencing data to identify oncogenic mutations that promote cancer across tumor types, group these mutations into families and develop a single small molecule therapy in a tumor-agnostic manner that targets a specific family of mutations.

The Research Associate Scientist - Discovery Biology scientist will be located in New York, NY. The scientist should have hands-on laboratory experiences using standard molecular and cellular biology techniques. She/He will participating in a team environment to validate allosteric oncogene targets, establish cell-based assays to evaluate compound activities against allosteric oncogene targets, and study drug mechanism of action.

Responsibilities

Key Duties & Responsibilities:
  • Engineer mammalian cell lines to harbor allosteric oncogene targets and validate their oncogenicity
  • Establish cell-based assays for compound evaluation using engineered cell lines
  • Evaluate compound activities against allosteric oncogene targets in engineered and cancer patient-derived cell lines
  • Develop counter screening assays for evaluating potential compound liability
  • Analyze, interpret and present experimental results to project teams
  • Collaborate and interact with colleagues to complete assigned research projects
  • Maintain clear and up-to-date experiment record in electronic lab notebook and prepare study reports

Qualifications

Qualifications:
  • BS or MS in biology, biochemistry, cell biology, molecular biology, pharmacology or a related scientific field
  • 2+ years of experience in cancer research or drug discovery in a pharmaceutical and/or biotech environment; applicants from academic research lab will also be considered
  • Experience in cell lines engineering, western blot, assay development, PCR, plasmid subcloning, nucleic acid sequencing analysis, and compound evaluation
  • Experience in high-throughput format assays such as HTRF and Alphalisa
  • Ability to work independently and in team environment
  • Must possess superior motivation, drive and aptitude for research


Work Environment:

This job operates in a professional office environment. This role routinely uses standard office equipment.

Physical Demands:

The physical demands described here are representative of those that must be met by an employee to successfully perform he essential functions of this job.

While performing the duties of this job, the employee is occasionally required to stand; walk; sit; used hands to fingers, handle, or feel objects, tools, or controls; reach with hands and arms; climb be stairs; talk or hear. The employee must occasionally lift or move office products and supplies, up to 20 lbs.

Black Diamond Therapeutics is an equal opportunity employer and welcomes and encourages all applications. Diversity and inclusion are important core values and will encourage our creativity and growth as a company. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.