AbbVie

Senior Scientist I, Protein Analytics

Employer
AbbVie
Location
Worcester, MA, United States
Posted
Jan 21, 2021
Ref
2008586
Required Education
Doctorate/PHD/MD
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

Senior Scientist I Job Description in ACG

We are searching for a highly motivated Senior Scientist I to join our Protein Analytics team at AbbVie Bioresearch Center in Worcester, MA. Our team is responsible for the development, qualification, and execution of analytical methods to provide product and process understanding for biological entities from discovery through commercial stages.

As a Senior Scientist I, you will be a part of the Analytical Characterization Group (ACG) within the Protein Analytics Department. ACG focuses on providing routine, investigative, and in-depth characterization analyses of AbbVie's biologics to support product and process development for early-phase, late-phase, and commercial programs using liquid chromatography mass spectrometry (LC-MS), spectroscopy and various other biophysical assays.

The successful candidate will contribute to the development and performance of analytical assays and will contribute to the continuous improvement and innovation within ACG and the Protein Analytics Department.

Key Responsibilities:
  • Independently perform LC-MS analyses (e.g., intact, reduced, sub-unit, peptide mapping, and disulfide bond mapping) of AbbVie's biologics to provide sequence verification, post-translational modification profiles, sequence variant levels, and disulfide bond profiles.
  • Independently perform separation methods (e.g., fractionation of variants) and biophysical methods of AbbVie's biologics to support characterization studies.
  • Design and execute experiments for method development and/or investigations.
  • Support process development by performing raw material analysis using vibrational spectroscopy and executing metabolomics experiments using LC-MS.
  • Generate and communicate precise, reliable, and reproducible data in a timely manner.
  • Organize and document experiments and results in an electronic laboratory notebook.
  • Author and review protocols, method development reports, and technical characterization reports.
  • Represent Protein Analytics Department in cross-functional program teams as Analytical Lead for AbbVie's biologics in development pipeline.
  • Maintain laboratory equipment, provide troubleshooting, and coordinate services/PMs.

Qualifications

Qualifications:
  • PhD or Masters in chemistry, biology, biochemistry or related technical discipline with typically 0-3 (PhD) or 7+ (MS) years of relevant experience in biotech/pharmaceutical industry setting.
  • Hands-on experience with protein mass spectrometry, liquid chromatography, capillary electrophoresis and protein biophysical characterization.
  • Strong fundamental understanding of protein structure, post-translational modifications, and analytical methods used for protein characterization.
  • Experience with bioinformatics tools to process and analyze mass spectrometry data.
  • Knowledge of vibrational spectroscopy (e.g., IR, NIR and Raman) and multivariate analysis is desirable.
  • Proficient with Windows 10 and Microsoft Office (Outlook, Excel, Word, and PowerPoint).
  • Excellent written communication, oral communication, organization, and multitasking skills.
  • Hardworking and motivated to drive both efficiency and quality in a fast-paced and collaborative environment.
  • Understand and adhere to corporate standards regarding code of conduct, safety, and appropriate handling of materials.

Significant Work Activities
Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)
Continuous standing for prolonged periods (more than 2 consecutive hours in an 8 hour day)
Travel
No
Job Type
Experienced
Schedule
Full-time
Job Level Code
IC
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.